SIT Inhibitors
Chemical inhibitors of SIT can disrupt its function through various mechanisms that target the signaling pathways SIT is involved in. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit SIT by hampering the phosphorylation events that are essential for its activation. Similarly, PP2, a selective inhibitor of Src family kinases, can interrupt the initiation of immunoreceptor signaling pathways that SIT is part of, thereby inhibiting its function. Dasatinib, which targets both Src family kinases and Abl kinases, can prevent the phosphorylation and subsequent activation of SIT, which is necessary for its role in T cell receptor signaling. LY294002 and Wortmannin, both PI3K inhibitors, can reduce the functional activity of SIT by preventing its role within PI3K-dependent signaling pathways, which are crucial for the full activation of SIT.
In addition to these, PD 98059 and U0126, as inhibitors of MEK, can suppress downstream signaling events within the MAPK/ERK pathway that SIT interacts with, leading to the inhibition of SIT's associated functions. SP600125, a JNK inhibitor, and SB203580, a p38 MAPK inhibitor, can disrupt the MAPK pathway where SIT signaling may intersect, thus inhibiting its activation. ZM 336372 can decrease the functional activity of SIT by inhibiting Raf kinase, which is influential in the MAPK/ERK signaling pathway. Rapamycin, by inhibiting mTOR, can lead to reduced SIT signaling function, as SIT is part of the complex signaling cascade in T cells where mTOR activity is a significant modulator. Lastly, Go6983, which inhibits protein kinase C, can prevent the phosphorylation of SIT, thereby reducing its functional signaling activity within the cell.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. SIT, being involved in signal transduction, relies on phosphorylation events. Staurosporine inhibits the kinases responsible for SIT phosphorylation, leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. Since SIT is involved in immunoreceptor signaling which relies on Src family kinases for initiation, PP2 can inhibit the activation of SIT by inhibiting these kinases. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a multi-kinase inhibitor that targets Src family kinases and Abl kinases. It can inhibit SIT by preventing its phosphorylation and activation, which are necessary for SIT's role in T cell receptor signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which is a part of the MAPK/ERK pathway. SIT is associated with T cell receptor signaling that interacts with the MAPK/ERK pathway. By inhibiting MEK, PD 98059 can suppress the downstream signaling that involves SIT. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. SIT-mediated signaling can involve PI3K for full activation. By inhibiting PI3K, LY294002 can reduce SIT's functional activity in the signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK pathway. SIT signaling may intersect with JNK pathways, and inhibition of JNK can disrupt SIT-mediated signaling events. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, upstream in the MAPK/ERK pathway. By inhibiting MEK1/2, U0126 can suppress the pathway's activation, leading to the inhibition of SIT's associated functions. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent PI3K inhibitor. By inhibiting PI3K, Wortmannin can lead to the functional inhibition of SIT by preventing its activity within PI3K-dependent signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Since SIT is involved in signaling pathways that can include p38 MAPK, inhibition of p38 MAPK can disrupt signals that would otherwise involve SIT activation. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
ZM 336372 is a potent inhibitor of the Raf kinase, which plays a role in the MAPK/ERK signaling pathway. By inhibiting Raf, this chemical can decrease the functional activity of SIT within this pathway. | ||||||