SIRT6 Activators
SIRT6 activators constitute a diverse group of chemicals that intricately modulate the activity of SIRT6, a NAD+-dependent histone deacetylase and ADP-ribosyltransferase involved in various cellular processes, including DNA repair, metabolism, and aging. Among these activators, Resveratrol emerges as a notable direct activator, enhancing the deacetylase activity of SIRT6 and modulating cellular processes related to SIRT6 activity. Additionally, compounds like Quercetin, Honokiol, and Suramin act as potential indirect activators, influencing signaling pathways associated with SIRT6 and thereby enhancing its expression or activity. The interplay between SIRT6 and other sirtuins is evident with compounds like Sirtinol, Selisistat (EX-527), AK-7, and Cambinol, which indirectly activate SIRT6 by influencing the crosstalk between different sirtuins. These chemicals showcase the complexity of sirtuin regulation and the potential compensatory upregulation of SIRT6 activity when specific sirtuin isoforms are inhibited.
Furthermore, the inclusion of UBCS039 as a selective SIRT6 inhibitor highlights the intricate autoregulation of SIRT6, where preventing auto-deacetylation enhances its catalytic activity. This unique mechanism emphasizes the importance of understanding the intricate regulatory networks governing SIRT6 function. NAD+, an essential cofactor for SIRT6, directly activates the enzyme by providing the necessary substrate for enzymatic reactions. The reliance of SIRT6 on NAD+ underscores the significance of cellular redox balance in modulating SIRT6 activity. In summary, the class of SIRT6 activators encompasses a range of chemicals that directly or indirectly modulate SIRT6 activity, impacting various cellular processes. Understanding the mechanisms by which these chemicals influence SIRT6 provides valuable insights into the intricate regulatory networks governing this critical enzyme's function in cellular homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol found in red wine and grapes. It has been shown to activate SIRT6, among other sirtuins, and may have potential benefits for age-related conditions. | ||||||
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
This compound found in magnolia bark has been studied for its potential to activate SIRT6, promoting longevity and metabolic health. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
A specific inhibitor of SIRT1 and SIRT2 that may indirectly activate SIRT6. Sirtinol influences the interplay between different sirtuins, potentially leading to compensatory upregulation of SIRT6 activity. The specific mechanisms by which Sirtinol affects SIRT6 necessitate further investigation for a comprehensive understanding of the underlying pathways. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid, found in various plants, has demonstrated SIRT6-activating properties and may have implications for combating age-related diseases. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $145.00 | 4 | |
A SIRT1 and SIRT2 inhibitor that may indirectly activate SIRT6. Cambinol influences the crosstalk between different sirtuins, potentially leading to compensatory upregulation of SIRT6 activity. The specific mechanisms by which Cambinol affects SIRT6 necessitate further investigation for a comprehensive understanding of the underlying pathways. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
A coenzyme involved in cellular redox reactions that acts as a cofactor for SIRT6. NAD+ is essential for the deacetylase activity of SIRT6, serving as a direct activator by providing the necessary substrate for enzymatic reactions. The intricate relationship between NAD+ and SIRT6 highlights the importance of cellular redox balance in modulating SIRT6 activity. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
A polysulfonated naphthylurea that may indirectly activate SIRT6. Suramin influences cellular signaling pathways associated with SIRT6, potentially enhancing its expression or activity. The specific interplay between Suramin and SIRT6 requires further investigation to elucidate the precise molecular mechanisms involved. | ||||||
Oxamflatin | 151720-43-3 | sc-205960 sc-205960A | 1 mg 5 mg | $151.00 $470.00 | 4 | |
A broad-spectrum histone deacetylase (HDAC) inhibitor that may indirectly activate SIRT6. Oxamflatin influences the acetylation status of histones, potentially impacting the epigenetic regulation of SIRT6 target genes. The intricate relationship between Oxamflatin and SIRT6 requires further exploration for a comprehensive understanding of the underlying mechanisms. | ||||||