Molecular structure of Oxamflatin, CAS Number: 151720-43-3
Oxamflatin (CAS 151720-43-3)
See product citations (4)
Alternate Names:
(2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid
Application:
Oxamflatin is a potent inhibitor of HDACs (histone deacetylases)
CAS Number:
151720-43-3
Purity:
≥95%
Molecular Weight:
342.37
Molecular Formula:
C17H14N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Oxamflatin acts as an inhibitory ligand for the enzyme active site metal ion of mammalian HDAC. HDACs deacetylate histones thereby allowing the histones to wrap DNA more tightly. This interaction affects gene expression. Oxamflatin elevates the expression of the extracellular matrix proteins fibronectin and gelsolin. Oxamflatin upregulates plasminogen activator inhibitor type 2 (PAI-2) expression with concomitant inhibition of urokinase (u-PA) gene and protein expression in HT-1080 and U-937 cells. Additionally, oxamflatin induces apoptosis in P-glyoprotein (Pgp)-positive and Pgp-negative multidrug resistant cells.
Oxamflatin (CAS 151720-43-3) References
- Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. | Kim, YB., et al. 1999. Oncogene. 18: 2461-70. PMID: 10229197
- The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity. | Dear, AE. and Medcalf, RL. 2000. Biochim Biophys Acta. 1492: 15-22. PMID: 11004477
- Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. | Peart, MJ., et al. 2003. Cancer Res. 63: 4460-71. PMID: 12907619
- Histone deacetylase inhibitors. | Monneret, C. 2005. Eur J Med Chem. 40: 1-13. PMID: 15642405
- Histone deacetylase inhibitors induce antigen specific anergy in lymphocytes: a comparative study. | Edens, RE., et al. 2006. Int Immunopharmacol. 6: 1673-81. PMID: 16979121
- Oxamflatin significantly improves nuclear reprogramming, blastocyst quality, and in vitro development of bovine SCNT embryos. | Su, J., et al. 2011. PLoS One. 6: e23805. PMID: 21912607
- Oxamflatin improves developmental competence of porcine somatic cell nuclear transfer embryos. | Park, SJ., et al. 2012. Cell Reprogram. 14: 398-406. PMID: 23013534
- Effects of histone deacetylase inhibitor oxamflatin on in vitro porcine somatic cell nuclear transfer embryos. | Hou, L., et al. 2014. Cell Reprogram. 16: 253-65. PMID: 24960409
- Oxamflatin treatment enhances cloned porcine embryo development and nuclear reprogramming. | Mao, J., et al. 2015. Cell Reprogram. 17: 28-40. PMID: 25548976
- HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. | Wang, YL., et al. 2016. Curr Mol Med. 16: 232-42. PMID: 26917266
- The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. | Faghihloo, E., et al. 2016. Cancer Gene Ther. 23: 396-399. PMID: 27767089
- A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. | Farr, GH., et al. 2020. Skelet Muscle. 10: 29. PMID: 33059738
- Oxamflatin: a novel compound which reverses malignant phenotype to normal one via induction of JunD. | Sonoda, H., et al. 1996. Oncogene. 13: 143-9. PMID: 8700540
Inhibitor of:
0610010K06Rik, FRG2B, GOLGA8B, GPI-PLD, Gvin1, H2-M10.3, H2-T24, H2al2y, hCG_1795065, hCG_2015138, HDAC, Histone cluster 1 H2AA2, LBA1, LDOC1L, Lipocalin-4, LOC100041107, MUP16, Olfr376, Tastin, WDR33, and ZNF136.Activator of:
Histone cluster 1 H2AH, Histone cluster 1 H2AI, Histone cluster 1 H3A, Histone cluster 1 H3I, Histone cluster 1 H4F, Histone cluster 1 H4G, Histone cluster 1 H4J, Histone cluster 2 H4A, RRP15, SIRT6, ZBTB37, ZNF322A, and ZNF579.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Oxamflatin, 1 mg | sc-205960 | 1 mg | $148.00 | |||
Oxamflatin, 5 mg | sc-205960A | 5 mg | $461.00 |