You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Oxamflatin acts as an inhibitory ligand for the enzyme active site metal ion of mammalian HDAC. HDACs deacetylate histones thereby allowing the histones to wrap DNA more tightly. This interaction affects gene expression. Oxamflatin elevates the expression of the extracellular matrix proteins fibronectin and gelsolin. Oxamflatin upregulates plasminogen activator inhibitor type 2 (PAI-2) expression with concomitant inhibition of urokinase (u-PA) gene and protein expression in HT-1080 and U-937 cells. Additionally, oxamflatin induces apoptosis in P-glyoprotein (Pgp)-positive and Pgp-negative multidrug resistant cells.
1. Sonoda, H., et al., 1996. Oxamflatin: a novel compound which reverses malignant phenotype to normal one via induction of JunD. Oncogene. 13(1): 143-9. PMID: 8700540
2. Kim, Y B., et al., 1999. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 18(15): 2461-70. PMID: 10229197
3. Dear, A E., et al., 2000. The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity. Biochimica et biophysica acta. 1492(1): 15-22. PMID: 11004477
4. Peart, Melissa J., et al., 2003. Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer research. 63(15): 4460-71. PMID: 12907619
See how others have used Oxamflatin. Click on the entry to view the PubMed entry .
PMID: # 29162813 Lalonde, J. et al. 2017. Nat Commun. 8: 1659.
PMID: # 26728316 Chan, CN. et al. 2016. Retrovirology. 13: 1.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.