SIRT5 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Suramin sodium acts as a SIRT5 modulator, engaging in selective binding that alters the enzyme's conformational dynamics. Its unique molecular architecture enables it to disrupt key protein interactions, influencing the regulation of mitochondrial metabolism. The compound exhibits distinctive reaction kinetics, characterized by a non-linear response in deacetylation rates. Furthermore, its hydrophilic nature enhances its interaction with cellular membranes, potentially impacting intracellular signaling cascades. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, is a well-known sirtuin inhibitor. It inhibits SIRT5 by serving as a non-competitive inhibitor, thereby influencing cellular metabolism and aging processes mediated by SIRT5. | ||||||
SIRT1/2 Inhibitor IV, Cambinol | 14513-15-6 | sc-204280 | 5 mg | $142.00 | 4 | |
SIRT1/2 Inhibitor IV, Cambinol, functions as a SIRT5 modulator by selectively targeting the enzyme's active site, leading to altered substrate affinity. Its unique structural features facilitate specific hydrogen bonding interactions, which can stabilize transient enzyme conformations. The compound exhibits a distinct kinetic profile, with a pronounced effect on the modulation of metabolic pathways. Additionally, its lipophilic characteristics may influence membrane permeability, affecting cellular localization and interaction with lipid rafts. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol is known to inhibit sirtuin activity. It can impede SIRT5 function by interfering with its deacetylase and demalonylase activities, affecting metabolic regulation and stress response pathways. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $85.00 | 32 | |
EX-527 selectively inhibits SIRT1 but has been shown to affect other sirtuins as well. Its inhibition of SIRT5 can impact cellular energy metabolism and stress response mechanisms. | ||||||
SIRT2 Inhibitor, AGK2 | 304896-28-4 | sc-202813A sc-202813 sc-202813B sc-202813C | 1 mg 5 mg 10 mg 25 mg | $45.00 $145.00 $310.00 $480.00 | 5 | |
AGK2 is a selective SIRT2 inhibitor but may exert inhibitory effects on other sirtuins like SIRT5, potentially impacting energy metabolism and cellular stress responses. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6, a small molecule activator of p53, also inhibits sirtuin activity. Its inhibition of SIRT5 can affect processes like mitochondrial metabolism and regulation of oxidative stress. | ||||||
Salermide | 1105698-15-4 | sc-224276 sc-224276A | 5 mg 10 mg | $70.00 $105.00 | 3 | |
Salermide, initially designed as an SIRT1 and SIRT2 inhibitor, can also affect SIRT5. Its inhibition of SIRT5 can play a role in modulating metabolic pathways and stress responses. | ||||||
SIRT2 Inhibitor II, AK-1 | 330461-64-8 | sc-364619 | 10 mg | $171.00 | ||
AK-1 is known for its inhibitory effect on SIRT2 but may also affect SIRT5. It can modulate metabolic and aging processes by inhibiting SIRT5's enzymatic activities. | ||||||
1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) | 309271-94-1 | sc-478554 | 10 mg | $390.00 | ||
Also called Inauhzin, this compound activates p53 and has been shown to inhibit sirtuins. Its effect on SIRT5 can influence pathways involved in metabolism and cellular stress responses. | ||||||