SIRP-β1 Activators
SIRP-β1 Activators consist of chemical compounds that, through their interaction with various cellular signaling pathways, facilitate the functional enhancement of SIRP-β1. Forskolin, by increasing cAMP levels, indirectly leads to the activation of PKA, which can phosphorylate SIRP-β1, thereby enhancing its involvement in immune cell signaling. PGE2 and Adenosine function through their specific receptors, EP and A2A respectively, to initiate signaling cascades that increase the activity of kinases, which in turn can directly phosphorylate SIRP-β1, consequently augmenting its function in immune response modulation.
Anandamide and S1P, through cannabinoid and S1P receptors, activate kinases that are capable of enhancing SIRP-β1's phosphorylation and activity within immune regulatory pathways. Similarly, UTP and LPA, by engaging P2Y and LPA receptors, initiate signaling events that lead to kinase activation, which may result in the phosphorylation and subsequent functional enhancement of SIRP-β1's role in immune cell communication.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate SIRP-β1, leading to its functional activation in immune signaling. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its E-prostanoid receptors, which can initiate signaling cascades that culminate in the activation of kinases that potentially phosphorylate SIRP-β1, thus enhancing its immune modulatory functions. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine binds to its receptors on immune cells, which modulates the activity of various kinases and phosphatases, potentially leading to the phosphorylation and activation of SIRP-β1 involved in immune cell signaling. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate binds to its G-protein coupled receptors, which may activate downstream kinases that phosphorylate SIRP-β1, enhancing its role in immune surveillance. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways, including those involved in inflammation, which could lead to the activation of kinases that phosphorylate SIRP-β1, enhancing its immune regulatory activities. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences several cellular pathways related to immunity and could lead to the activation of kinases that subsequently phosphorylate and activate SIRP-β1 in immune signaling. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin binds to TRPV1 receptors and influences downstream signaling pathways, which includes the activation of kinases that could phosphorylate and enhance the activity of SIRP-β1 in immune processes. | ||||||