Sipar Activators
Sipar Activators encompass a diverse array of chemical compounds that, through their targeted effects on various signaling pathways, augment the functional activity of Sipar. Forskolin and Genistein indirectly enhance Sipar activity by modulating levels of cAMP and by inhibiting tyrosine kinase signaling, respectively, thereby influencing cellular processes where Sipar is involved. Sphingosine-1-phosphate and Thapsigargin act through lipid and calcium signaling pathways, potentially leading to Sipar activation by altering the intracellular environment in a manner that favors Sipar's role. Similarly, activation of protein kinase C by PMA and inhibition of competitive kinase signaling by EGCG are mechanisms through which Sipar activity may be indirectly enhanced, as these compounds influence phosphorylation patterns and cellular responses where Sipar is essential.
PI3K inhibitors LY294002 and Wortmannin,along with MAPK pathway modulators SB203580 and U0126, contribute to the network of Sipar activators by altering signaling dynamics to favor Sipar's role within the cell. The inhibition of these key kinases leads to a shift in signaling that can enhance the pathways in which Sipar operates. Additionally, A23187, by increasing intracellular calcium, can activate calcium-dependent signaling pathways that may result in the increased activity of Sipar. Staurosporine, despite its broad kinase inhibition profile, might inadvertently promote Sipar activation by disrupting inhibitory signals within complex signaling networks. Collectively, these chemical activators work in concert to fine-tune cellular signaling networks, leading to the enhanced activity of Sipar without the need for direct activation or upregulation of its expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels within the cell. Elevated cAMP activates protein kinase A (PKA). PKA then phosphorylates specific substrates that can lead to activation of Sipar by promoting cellular processes in which Sipar is a critical player. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that acts as a tyrosine kinase inhibitor. By inhibiting tyrosine kinase activity, Genistein may reduce competitive signaling pathways, resulting in the indirect enhancement of Sipar's functional role through relief of inhibitory control. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that binds to its specific G-protein-coupled receptors, initiating a signaling cascade that could lead to the activation of Sipar by modulating intracellular processes that Sipar regulates. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels. Elevated calcium can activate calcium-dependent signaling pathways, potentially enhancing Sipar activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and functions as a potent protein kinase C (PKC) activator. Activation of PKC can lead to phosphorylation events that enhance the activity of Sipar within its associated signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea that acts as an inhibitor of various protein kinases. By modulating kinase activity, EGCG could indirectly enhance Sipar's function in pathways where kinase inhibition leads to increased activity of Sipar. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 may enhance Sipar activity indirectly by altering downstream signaling pathways where Sipar is involved in the response to changes in PI3K activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a steroidal metabolite that acts as a potent and irreversible inhibitor of PI3K. Similar to LY294002, Wortmannin's inhibition of PI3K could lead to the enhancement of Sipar activity by affecting associated signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 may shift cellular signaling in favor of pathways that activate Sipar, leading to its functional enhancement. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, enzymes upstream of ERK in the MAPK pathway. By inhibiting MEK1/2, U0126 could indirectly enhance the activity of Sipar by affecting signaling pathways in which Sipar has a functional role. | ||||||