Shh Activators
Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SAG Analog (trans-isomer) | sc-396539 | 1 mg | $195.00 | |||
SAG Analog (trans-isomer) functions as a potent modulator of the sonic hedgehog (Shh) signaling pathway, characterized by its ability to stabilize the Shh ligand. This compound engages in specific hydrophobic interactions with receptor proteins, enhancing the affinity for downstream effectors. Its unique structural conformation allows for selective binding, influencing the conformational dynamics of the pathway. The reaction kinetics reveal a non-competitive inhibition profile, altering the signaling cascade's efficiency. | ||||||
SAG Analog (cis-isomer) | 1401532-77-1 | sc-396546 | 1 mg | $195.00 | ||
SAG Analog (cis-isomer) exhibits a distinctive role in modulating the sonic hedgehog (Shh) signaling pathway through its unique stereochemistry. This isomer demonstrates enhanced solubility and reactivity, facilitating rapid interactions with Shh receptors. Its ability to form transient complexes with key signaling intermediates alters the pathway's activation threshold. Additionally, the cis configuration influences molecular flexibility, impacting downstream signaling dynamics and cellular responses. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $56.00 $180.00 | 18 | |
Directly activates the Smoothened receptor, enhancing Shh signaling. | ||||||
Smoothened Agonist, HCl | 364590-63-6 | sc-202814 sc-202814A | 1 mg 5 mg | $206.00 $510.00 | 31 | |
SAG directly activates Smoothened, effectively promoting Shh signaling. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Necessary for Shh ligand processing and activation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Induces Shh expression through VDR (Vitamin D Receptor). | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, thereby stabilizing β-catenin and indirectly upregulating Shh. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Modulates Shh expression via retinoic acid receptors. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases cAMP levels, leading to enhanced Shh expression. | ||||||
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $80.00 $96.00 | 1 | |
Though primarily an inhibitor, at low doses can act as a Smoothened agonist. | ||||||