SH2D3A Activators
SH2D3A employ diverse molecular mechanisms to modulate the activity of this protein. Phosphatidylserine, for instance, directly interacts with the SH2 domain of SH2D3A, a region known for its affinity to phosphotyrosine residues. By binding to this domain, phosphatidylserine increases SH2D3A's activity. Src kinase inhibitor-1, on the other hand, acts indirectly by inhibiting Src family kinases. These kinases typically phosphorylate a variety of substrates; when inhibited, they allow SH2D3A to engage more freely with its preferred phosphorylated substrates, thereby amplifying its activity. Similarly, Epidermal Growth Factor (EGF) triggers receptor tyrosine kinase signaling pathways, which result in the phosphorylation of target proteins that SH2D3A recognizes, thus enhancing its activity. Insulin achieves a comparable effect through its own receptor signaling pathway, leading to the activation of SH2D3A by promoting the tyrosine phosphorylation of insulin receptor substrates.
Platelet-Derived Growth Factor BB (PDGF-BB), which induces tyrosine phosphorylation of associated proteins that then interact with SH2D3A. Zoledronic Acid, while distinct in its mechanism, also contributes to SH2D3A activation by inhibiting farnesyl pyrophosphate synthase, causing an accumulation of isopentenyl pyrophosphate, a potential phosphate donor for kinases that target SH2D3A's substrates. Hydrogen peroxide represents a more oxidative approach, modifying protein cysteine residues and thus influencing the regulatory activity of kinases and phosphatases connected to SH2D3A. Phosphatase inhibitors like Calyculin A and Okadaic Acid lead to increased phosphorylation levels of SH2D3A-associated proteins by inhibiting PP1 and PP2A, respectively. Forskolin activates SH2D3A by raising cAMP levels, which in turn activate PKA and subsequent phosphorylation events that promote SH2D3A interaction. Lastly, Retinoic Acid and LY294002 activate SH2D3A by modulating cell differentiation and PI3-kinase activity, respectively, altering the balance of kinases and phosphatases that ultimately determine the phosphorylation status of SH2D3A's interacting proteins.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $78.00 | ||
Phosphatidylserine directly activates SH2D3A by binding to its SH2 domain, which is known to interact with phosphotyrosine-containing ligands, leading to an increase in SH2D3A activity. | ||||||
Src kinase inhibitor I | 179248-59-0 | sc-204303 sc-204303A | 1 mg 10 mg | $52.00 $200.00 | 11 | |
Src kinase inhibitor-1 activates SH2D3A by inhibiting Src family kinases that phosphorylate substrates that SH2D3A may bind to; this allows more SH2D3A to be available to interact with its specific phosphorylated substrates, thereby increasing its functional activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can activate SH2D3A through the insulin receptor signaling pathway, which involves the tyrosine phosphorylation of insulin receptor substrates that interact with SH2D3A, leading to its functional activation. | ||||||
Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | sc-203279 sc-203279A | 5 g 10 g | $82.00 $120.00 | 9 | |
Platelet-Derived Growth Factor BB activates SH2D3A by inducing tyrosine phosphorylation of PDGF receptor-associated proteins, which then interact with the SH2 domain of SH2D3A to activate it. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide can oxidize cysteine residues in proteins, potentially altering the activity of kinases and phosphatases that regulate proteins interacting with SH2D3A, leading to its activation. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic Acid activates SH2D3A by inhibiting farnesyl pyrophosphate synthase, leading to the accumulation of isopentenyl pyrophosphate, which can serve as a phosphate donor for tyrosine kinases that phosphorylate proteins interacting with SH2D3A. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A activates SH2D3A by inhibiting protein phosphatases PP1 and PP2A, resulting in increased phosphorylation levels of proteins that associate with SH2D3A's SH2 domain, thus enhancing SH2D3A activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid activates SH2D3A by a similar mechanism as Calyculin A, by inhibiting PP1 and PP2A phosphatases, leading to increased tyrosine phosphorylation and binding of substrates to SH2D3A's SH2 domain. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates SH2D3A by elevating cAMP levels, which can activate protein kinase A (PKA) and lead to phosphorylation events that promote the interaction of phosphoproteins with SH2D3A, thereby activating it. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid activates SH2D3A by differentiating cells and potentially inducing the expression of specific phosphatases or kinases that modify the phosphorylation state of proteins that interact with SH2D3A, resulting in its activation. | ||||||