Sgo2 Inhibitors
In the context of Sgo2 inhibitors, we would be referring to agents that indirectly impact the cell cycle and chromosomal segregation processes with which Sgo2 is associated. These compounds generally target microtubules, kinases, or other proteins essential for cell cycle progression and mitotic spindle assembly, which are critical for the accurate segregation of chromosomes.
The aforementioned chemicals do not interact directly with Sgo2 but can influence the cellular environment and the processes in which Sgo2 is crucial. For example, drugs like Paclitaxel and Vinblastine disrupt microtubule dynamics, which is a key part of the mitotic spindle apparatus necessary for chromosome segregation. CDK and kinase inhibitors like Purvalanol A and Roscovitine can halt the cell cycle at points where Sgo2's role is critical, thereby indirectly affecting its function. By altering the timing or integrity of the mitotic machinery, these compounds may influence the proper localization and function of Sgo2, which is central to safeguarding cohesin complexes during mitosis and ensuring the fidelity of chromosome segregation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
A microtubule-disrupting agent that inhibits mitotic spindle formation, potentially influencing Sgo2's protective function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
An alkaloid that binds to tubulin and inhibits microtubule polymerization, affecting mitotic spindle assembly and Sgo2 function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
A small molecule inhibitor of the mitotic kinesin Eg5, which may alter spindle dynamics and indirectly affect Sgo2. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
A cyclin-dependent kinase (CDK) inhibitor that can halt cell cycle progression, possibly influencing Sgo2's role in chromosome segregation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A CDK inhibitor that can affect cell cycle progression, thereby having an indirect effect on Sgo2's function. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
A Polo-like kinase 1 (Plk1) inhibitor that can interrupt mitotic entry and spindle assembly, potentially impacting Sgo2. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor that can disrupt chromosome alignment and segregation, indirectly affecting Sgo2's function. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An Aurora kinase A inhibitor that can interfere with mitosis, which might influence Sgo2's protective role at centromeres. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $114.00 $166.00 $947.00 | 19 | |
A small molecule that inhibits the anaphase-promoting complex/cyclosome (APC/C), potentially impacting Sgo2 function indirectly by altering timing of cohesin release. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
A chemical that inhibits Eg5, affecting spindle dynamics, with potential indirect implications for Sgo2's role in mitosis. | ||||||