SF4 Activators

SF4, also known as Splicing Factor 4, is a protein that plays a critical role in the process of pre-mRNA splicing, an essential step in gene expression in eukaryotic cells. This process involves the removal of non-coding sequences (introns) from pre-messenger RNA (pre-mRNA) and the joining of the coding sequences (exons), leading to the formation of mature messenger RNA (mRNA) that can be translated into proteins.As a splicing factor, SF4 is part of a larger complex of proteins and RNA molecules known as the spliceosome. The spliceosome is responsible for recognizing and accurately removing introns from pre-mRNA. SF4 contributes to the assembly and stabilization of this complex, ensuring the precise and efficient splicing of pre-mRNA.

The precise regulation of splicing is crucial for the generation of protein diversity and the proper functioning of cells. Alternative splicing, where the same pre-mRNA is spliced in different ways to produce multiple mRNA variants, is a key mechanism for expanding protein diversity. SF4, by participating in the splicing process, indirectly influences this diversity.Mutations or dysregulation in splicing factors like SF4 can lead to aberrant splicing, which has been implicated in various diseases, including cancer and genetic disorders. Understanding the role and mechanism of splicing factors is therefore essential in understanding the molecular basis of these diseases.SF4, like other splicing factors, is also a subject of interest in research. Modulating the activity of splicing factors could correct aberrant splicing patterns in diseases, offering a novel avenue for intervention