Molecular structure of Tetrabenazine, CAS Number: 58-46-8
Tetrabenazine (CAS 58-46-8)
Alternate Names:
Rubigen
Application:
Tetrabenazine is a potent inhibitor of vesicular monoamine uptake
CAS Number:
58-46-8
Purity:
≥98%
Molecular Weight:
317.42
Molecular Formula:
C19H27NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tetrabenazine is a potent inhibitor of vesicular monoamine uptake; depletes stores of serotonin, dopamine and noradrenalin. Binds with high affinity (IC50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors.
Tetrabenazine (CAS 58-46-8) References
- Tetrabenazine in the treatment of hyperkinetic movement disorders. | Kenney, C. and Jankovic, J. 2006. Expert Rev Neurother. 6: 7-17. PMID: 16466307
- Role of tetrabenazine for Huntington's disease-associated chorea. | Poon, LH., et al. 2010. Ann Pharmacother. 44: 1080-9. PMID: 20442355
- Tetrabenazine for the treatment of tardive dyskinesia. | Leung, JG. and Breden, EL. 2011. Ann Pharmacother. 45: 525-31. PMID: 21487088
- Tetrabenazine for the treatment of chorea and other hyperkinetic movement disorders. | Jankovic, J. and Clarence-Smith, K. 2011. Expert Rev Neurother. 11: 1509-23. PMID: 22014129
- Tetrabenazine for the treatment of hyperkinetic movement disorders: a review of the literature. | Chen, JJ., et al. 2012. Clin Ther. 34: 1487-504. PMID: 22749259
- Structural mechanisms for VMAT2 inhibition by tetrabenazine. | Dalton, MP., et al. 2024. Elife. 12: PMID: 38517752
- Tetrabenazine-induced depletion of brain monoamines: characterization and interaction with selected antidepressants. | Pettibone, DJ., et al. 1984. Eur J Pharmacol. 102: 425-30. PMID: 6489435
- Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine. | Scherman, D., et al. 1983. Proc Natl Acad Sci U S A. 80: 584-8. PMID: 6572908
- Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. | Reches, A., et al. 1983. J Pharmacol Exp Ther. 225: 515-21. PMID: 6864517
- Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. | Peter, D., et al. 1996. J Biol Chem. 271: 2979-86. PMID: 8621690
Inhibitor of:
1110021L09Rik, C6orf192, DBH, Dopamine, GPR162, LEP503, Mtvr2, Muted, NCDN, PNKD, Snapin, TAAR7B, TRH-DE, VMAT 1, VMAT 2, Vmn2r34, and Vmn2r6.Activator of:
CD92, DDC, DRD1a, proenkephalin A, and SF4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tetrabenazine, 10 mg | sc-204338 | 10 mg | $165.00 | |||
Tetrabenazine, 50 mg | sc-204338A | 50 mg | $707.00 |