SETX Inhibitors
SETX inhibitors constitute a diverse array of chemicals that can modulate the activity of the Senataxin (SETX) protein. These inhibitors exert their effects through various mechanisms, either directly targeting SETX or indirectly influencing its function by perturbing cellular processes related to transcription and DNA repair. Actinomycin D, a potent antibiotic, inhibits RNA synthesis by binding to DNA and RNA, disrupting the transcription process. Camptothecin and Etoposide target DNA topoisomerases, disrupting DNA replication and transcription. Flavopiridol, a cyclin-dependent kinase inhibitor, affects cell cycle dynamics, indirectly influencing SETX activity. Alpha-Amanitin specifically inhibits RNA polymerase II, impacting mRNA synthesis and SETX-mediated repair. 5-Fluorouracil interferes with nucleotide metabolism, potentially affecting transcription and DNA repair processes.
Rifampicin, an antibiotic, inhibits bacterial RNA polymerase and may impact eukaryotic transcription processes involving SETX. Chemicals like 8-Oxoguanine and Thioguanine, which induce DNA damage, can influence SETX function, particularly in transcription-coupled DNA repair. Trabectedin interferes with DNA transcription by binding to DNA minor grooves, while Mitomycin C forms DNA crosslinks, inhibiting replication and transcription. 6-Thioguanine, a thiopurine analog, disrupts nucleotide metabolism, potentially affecting SETX function in DNA repair. These SETX inhibitors provide valuable tools for exploring the intricate mechanisms governing SETX activity and its role in cellular processes related to transcription and DNA repair. Understanding the specific biochemical and cellular pathways affected by these chemicals enhances our knowledge of SETX regulation, paving the way for targeted modulation of its function in various physiological contexts.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D, an antibiotic, inhibits RNA synthesis by binding to DNA and RNA, disrupting the transcription process. As SETX is involved in transcription-coupled DNA repair, the inhibition of RNA synthesis by Actinomycin D indirectly hinders SETX function, potentially impacting its role in DNA repair mechanisms. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin, a natural alkaloid, inhibits DNA topoisomerase I, leading to the formation of DNA cleavage complexes. This interference with DNA topoisomerases disrupts DNA replication and transcription. As SETX is implicated in transcription-coupled DNA repair, the inhibition of DNA topoisomerase I by Camptothecin may affect SETX-mediated repair processes. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, forms a complex with DNA-topoisomerase II, preventing the re-ligation of DNA strands. By interfering with topoisomerase II activity, Etoposide disrupts DNA replication and transcription. This disruption in DNA processes may impact SETX function, particularly in the context of transcription-coupled DNA repair. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol, a cyclin-dependent kinase inhibitor, disrupts cell cycle progression by inhibiting CDKs. As SETX activity is influenced by cell cycle dynamics, the inhibition of CDKs by Flavopiridol may indirectly modulate SETX function, potentially affecting its role in DNA repair mechanisms. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Alpha-Amanitin, a cyclic peptide toxin, specifically inhibits RNA polymerase II, a key enzyme involved in mRNA synthesis. By targeting RNA polymerase II, Alpha-Amanitin disrupts transcription processes. As SETX is implicated in transcription-coupled DNA repair, the inhibition of RNA polymerase II may impact SETX-mediated repair mechanisms, providing a potential avenue for modulating SETX activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil (5-FU), a pyrimidine analog, disrupts nucleotide synthesis and incorporates into RNA and DNA. The interference with nucleotide metabolism may affect various cellular processes, including transcription and DNA repair. As SETX participates in transcription-coupled DNA repair, the perturbation of these processes by 5-FU could influence SETX-mediated repair mechanisms. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin, an antibiotic, inhibits bacterial RNA polymerase, disrupting RNA synthesis. While primarily used for bacterial infections, the inhibition of RNA polymerase by Rifampicin may have implications for eukaryotic cells, potentially impacting transcription processes involving SETX. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
Thioguanine, an analog of guanine, can be incorporated into DNA, disrupting nucleotide metabolism and interfering with DNA replication and transcription. The perturbation of these processes may have implications for SETX function, particularly in the context of transcription-coupled DNA repair. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C, an antibiotic, forms DNA crosslinks, inhibiting DNA replication and transcription. The interference with these processes may affect SETX function, particularly in the context of transcription-coupled DNA repair. The formation of DNA adducts by Mitomycin C could influence the repair mechanisms involving SETX, providing a potential means to modulate its activity. | ||||||