SETD6 Activators
SETD6, or SET Domain Containing 6, is a protein encoded by the SETD6 gene in humans. It belongs to the SET domain protein family, which is known for its involvement in histone modification and chromatin remodeling. Histone modifications play a critical role in regulating gene expression and DNA repair, influencing a wide range of cellular processes.SETD6 is characterized by its SET domain, a region involved in the methylation of histone proteins. Specifically, SETD6 acts as a histone methyltransferase that primarily targets histone H2A. It adds a methyl group to lysine 20 of histone H2A (H2AK20me1), a modification that has implications for the structure and function of chromatin.
The methylation of histones by SETD6 is associated with the regulation of gene expression. This modification can influence how tightly DNA is wound around histones, affecting the accessibility of DNA to transcription factors and, consequently, the transcription of genes. Through this mechanism, SETD6 plays a role in controlling various cellular processes, including cell cycle progression, development, and differentiation.In addition to its role in histone modification, there is growing interest in the involvement of SETD6 in various diseases, particularly in cancer. Aberrant histone modification patterns are a hallmark of many cancers, and enzymes like SETD6 that regulate these modifications can contribute to the development and progression of cancer.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, may affect epigenetic regulation, potentially influencing SETD6 activity indirectly. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase inhibitor, potentially affecting chromatin structure and gene expression relevant to SETD6. | ||||||
Methylstat | 1310877-95-2 | sc-507374 | 10 mg | $480.00 | ||
Methylstat is a JMJD2 histone demethylase inhibitor, which may influence histone modification states and intersect with SETD6 functions. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is a G9a histone methyltransferase inhibitor, potentially impacting chromatin modifications and processes involving SETD6. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, another DNA methyltransferase inhibitor, can affect epigenetic states and potentially influence SETD6 activity. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a histone methyltransferase inhibitor, specifically targeting SUV39H1, and could indirectly affect SETD6 activity. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is an inhibitor of the G9a and GLP histone methyltransferases, potentially influencing processes involving SETD6. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
JIB-04 is a pan-inhibitor of Jumonji family histone demethylases, potentially affecting histone modification states relevant to SETD6. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 is a p300/CBP histone acetyltransferase inhibitor, which might influence chromatin states and intersect with SETD6 functions. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
LBH589 is a potent histone deacetylase inhibitor, affecting chromatin structure and gene expression potentially relevant to SETD6. | ||||||