SERPINE3 Inhibitors
SERPINE3, predicted to enable serine-type endopeptidase inhibitor activity, is implicated in the negative regulation of endopeptidase activity. Its predicted localization in the extracellular space emphasizes its role in modulating extracellular protease activities. The serine-type endopeptidase inhibitor function suggests that SERPINE3 plays a crucial role in controlling the activity of serine proteases, which are involved in numerous physiological and pathological processes.
Inhibition of SERPINE3 can be achieved through direct or indirect means. Direct inhibitors, such as aprotinin, PPACK, and nafamostat, target the serine-type endopeptidase activity of SERPINE3 in the extracellular space, blocking its inhibitory function on serine proteases. Indirect inhibitors, including epsilon-aminocaproic acid and tranexamic acid, disrupt the plasmin-mediated negative regulation of endopeptidase activity, indirectly influencing SERPINE3. Additionally, other compounds, such as danaparoid and gabexate mesylate, interfere with the balance of various protease activities, affecting the protease-mediated negative regulation of endopeptidase activity and potentially impacting SERPINE3. These diverse mechanisms of inhibition highlight the intricate role of SERPINE3 in modulating extracellular protease activities and suggest potential avenues for intervention in relevant biological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $112.00 $408.00 $3000.00 | 51 | |
Serine protease inhibitor inhibiting various endopeptidases, potentially directly inhibiting SERPINE3 by competitively binding to serine-type endopeptidase active sites in the extracellular space. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $82.00 $306.00 | 4 | |
Broad-spectrum serine protease inhibitor, potentially directly inhibiting SERPINE3 by interfering with serine-type endopeptidase activity in the extracellular space. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $43.00 $183.00 $312.00 $624.00 $2081.00 $4474.00 | 5 | |
Serine protease inhibitor blocking the activity of various proteases, potentially directly inhibiting SERPINE3 by targeting its serine-type endopeptidase activity in the extracellular space. | ||||||
Tranexamic acid | 1197-18-8 | sc-204921 sc-204921A | 5 g 10 g | $29.00 $50.00 | 10 | |
Antifibrinolytic agent inhibiting plasmin activity, potentially indirectly inhibiting SERPINE3 by disrupting the plasmin-mediated negative regulation of endopeptidase activity. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $65.00 $122.00 $428.00 $851.00 $1873.00 $4994.00 | 33 | |
Serine protease inhibitor, potentially directly inhibiting SERPINE3 by blocking serine-type endopeptidase activity in the extracellular space. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $281.00 $947.00 $1574.00 | 14 | |
Cysteine protease inhibitor, potentially indirectly inhibiting SERPINE3 by influencing the balance of different protease activities and disrupting the protease-mediated negative regulation of endopeptidase activity. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Serine protease inhibitor with anti-inflammatory properties, potentially directly inhibiting SERPINE3 by blocking serine-type endopeptidase activity in the extracellular space. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Protease inhibitor affecting various protease families, potentially indirectly inhibiting SERPINE3 by modulating the balance of protease activities and disrupting the protease-mediated negative regulation of endopeptidase activity. | ||||||