Septin 8 Inhibitors
Septin 8 is a member of the septin family of GTP-binding proteins, which play a crucial role in cell division, cytokinesis, and maintaining cellular integrity by contributing to the cytoskeleton's structure. Septins, including Septin 8, form filamentous structures and are involved in various cellular processes, such as vesicle trafficking, apoptosis, and cellular compartmentalization. They act as a scaffold, organizing other proteins at specific cellular locations, and are critical for the spatial arrangement of the cytoskeleton. Septin 8, in particular, has been implicated in the regulation of cell division and is believed to be essential for the completion of cytokinesis. Its proper function is vital for the successful separation of daughter cells, highlighting its importance in cellular reproduction and growth.
The inhibition of Septin 8 can lead to significant cellular dysfunction, primarily impacting processes related to cell division and integrity. Mechanisms of inhibition may involve alterations in the protein's ability to bind GTP, which is essential for its activity and the formation of septin filaments. Inhibitory factors might also disrupt the complex formation between Septin 8 and other septin family members or proteins necessary for its function, thus impairing the septin complex's ability to serve as a scaffold and organize other cellular components. Additionally, post-translational modifications such as phosphorylation, ubiquitination, or sumoylation can modulate Septin 8's activity and stability, and any dysregulation in these processes could result in its inhibition. Environmental stresses or cellular signals that lead to the mislocalization of Septin 8 within the cell can further inhibit its function, preventing it from participating in crucial processes at the correct cellular sites. The inhibition of Septin 8 underscores the delicate balance required for cellular division and integrity, emphasizing the complex regulation of septin proteins in maintaining cellular homeostasis and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA synthesis, which in turn can block the transcription of genes into mRNA. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is known to inhibit protein synthesis by blocking the translocation step in translation, blocking peptide chain elongation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a crucial role in protein synthesis and cell growth. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil (5-FU) is a nucleotide analogue that gets incorporated into RNA and DNA, leading to disruption of synthesis and function. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
This compound inhibits inosine monophosphate dehydrogenase, leading to a decrease in guanosine production and subsequent inhibition of RNA and DNA synthesis. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, blocking DNA unwinding and replication, and thus, affecting gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin inhibits RNA polymerase II, which is responsible for transcribing mRNA, thereby blocking gene expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB inhibits RNA polymerase II, blocking the elongation phase of RNA transcription. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and disrupts its function. Since Hsp90 stabilizes many client proteins, its inhibition can reduce protein expression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can modulate various signaling pathways, potentially impacting protein expression. | ||||||