Septin 14 Activators
Septin 14 activators are specialized chemical entities that target unique signaling mechanisms, ultimately leading to the potentiation of Septin 14's function within the cell. Forskolin stands out as it raises intracellular cyclic AMP levels, which in turn activates protein kinase A (PKA). PKA then potentially phosphorylates Septin 14, thus enhancing its role in cytoskeletal organization and other cellular processes. The action of phorbol 12-myristate 13-acetate (PMA), as a protein kinase C (PKC) activator, is crucial as it may lead to the phosphorylation and subsequent activation of Septin 14, thereby influencing cell division and vesicle trafficking. In parallel, the lipid signaling agent, sphingosine-1-phosphate, could stabilize and activate Septin 14, reinforcing its role in membrane dynamics and cytoskeletal structuring, while thapsigargin elevates intracellular calcium levels, potentially activating calcium-dependent kinases that could enhance the activity of Septin 14 in cellular signaling.
The kinase inhibitor epigallocatechin gallate (EGCG) and PI3K inhibitors LY294002 and Wortmannin could indirectly enhance Septin 14 activity by decreasing competitive phosphorylation events, allowing more specific activation pathways for Septin 14 to prevail. Okadaic acid, through its inhibition of protein phosphatases, may lead to a net increase in Septin 14 phosphorylation, implying an enhancement of its cellular functions. Microtubule-affecting agents like paclitaxel (taxol), by stabilizing microtubules, could prompt Septin 14 to compensate, thus enhancing its structural maintenance role. Furthermore, anisomycin activates stress-activated protein kinase pathways, which may indirectly activate Septin 14, enhancing its stress response functions. Lastly, dibutyryl-cAMP, a cAMP analogue, activates PKA, which is likely to phosphorylate and thus enhance Septin 14's activity in processes such as vesicle trafficking, highlighting the diverse yet specific influence these activators exert on Septin 14's cellular roles.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly elevates intracellular cyclic AMP (cAMP) levels. Increased cAMP activates PKA (protein kinase A), which can phosphorylate Septin 14, leading to its functional enhancement in cellular processes like cytoskeletal organization. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a direct activator of protein kinase C (PKC), which is involved in the phosphorylation of Septin proteins, thereby potentially enhancing Septin 14's role in cell division and vesicle trafficking. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate engages in lipid signaling pathways, which are known to interact with Septin filaments. This interaction could lead to the stabilization and functional enhancement of Septin 14 in membrane dynamics and cytoskeletal structuring. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin increases intracellular calcium levels by inhibiting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). Elevated calcium can activate calcium-dependent kinases that phosphorylate Septin 14, enhancing its activity within the cell. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a kinase inhibitor that can lead to the reduction of competitive phosphorylation events, indirectly increasing the activity of Septin 14 by allowing its specific phosphorylation pathways to be more active. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that changes the activity of downstream signaling pathways, such as the Akt pathway, potentially leading to an enhanced role of Septin 14 in processes like cell division and intracellular transport. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that alters signaling pathways to affect cytoskeletal dynamics. Through this pathway alteration, Septin 14 could be more actively engaged in its role of maintaining cellular structures. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, which leads to an increase in phosphorylation levels of various proteins. This may enhance Septin 14 activity by reducing its dephosphorylation. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can lead to an increased interaction with Septin 14, which is known to associate with microtubules, potentially enhancing its structural role in the cell. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinase pathways (SAPKs), which could lead to the indirect activation of Septin 14 by promoting its role in stress response within the cell. | ||||||