SEL-10 Inhibitors
Chemical inhibitors of SEL-10 can interfere with the protein's ability to facilitate the ubiquitination and subsequent degradation of target proteins. Emodin, for instance, disrupts the ubiquitin-proteasome pathway by altering the activity of proteasome enzymes, leading to the accumulation of proteins that would normally be degraded. This accumulation indirectly inhibits SEL-10's function. Similarly, Chloroquine, by impairing lysosomal function and autophagy, indirectly affects SEL-10's role since both processes are involved in the degradation of cellular components, including those targeted by SEL-10. Proteasome inhibitors such as MG132, Lactacystin, Bortezomib, Carfilzomib, Ixazomib, Oprozomib, and Epoxomicin all contribute to the inhibition of SEL-10 by preventing the proteasome from degrading ubiquitinated substrates. This stabilization of SEL-10 substrates occurs because these inhibitors block the proteolytic activity that would typically reduce the levels of these proteins.
Other compounds like Withaferin A and Celastrol exert their effects similarly by hindering proteasomal activity, which is crucial for the degradation process that SEL-10 is part of. Curcumin, too, is known to inhibit the proteasome, resulting in increased levels of SEL-10 substrates within the cell. This buildup indicates that SEL-10 is unable to perform its normal function of targeting these proteins for degradation. The common thread among these chemical inhibitors is their capacity to disrupt the normal ubiquitin-proteasome pathway, leading to the stabilization of proteins that SEL-10 would typically help to turn over, thus indirectly inhibiting the functional role of SEL-10.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
Emodin can inhibit the ubiquitin-proteasome pathway by affecting the activity of proteasome enzymes, which could lead to the functional inhibition of SEL-10 by preventing the degradation of proteins that SEL-10 targets for ubiquitination. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to disrupt lysosomal function and autophagy, a process that can be linked to the degradation pathways SEL-10 is involved with. By altering the cellular degradative capacity, chloroquine can indirectly inhibit SEL-10's ability to mediate the degradation of its target proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of ubiquitinated proteins, which could result in the stabilization of SEL-10 substrates, effectively inhibiting SEL-10's role in their turnover. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin specifically inhibits the proteasome's catalytic activity, which could lead to an accumulation of SEL-10 substrates, indirectly inhibiting SEL-10's function in protein ubiquitination and subsequent degradation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the 26S proteasome, leading to the buildup of polyubiquitinated proteins. Since SEL-10 depends on the proteasome to degrade its targets, inhibition by Bortezomib can indirectly inhibit the functional role of SEL-10. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
Carfilzomib is a selective proteasome inhibitor that can impede the degradation of proteins targeted by SEL-10, thereby indirectly inhibiting the function of SEL-10 by stabilizing its substrates. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
Ixazomib is a proteasome inhibitor that can interfere with the degradation of ubiquitinated proteins, which are substrates of SEL-10, thereby indirectly inhibiting SEL-10's function by reducing the turnover of these proteins. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
Oprozomib is another proteasome inhibitor that could lead to an accumulation of SEL-10 substrates, indirectly inhibiting the functional activity of SEL-10 by preventing the proteasomal degradation of its target proteins. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is a proteasome inhibitor that can indirectly inhibit SEL-10 by stabilizing the proteins it targets for ubiquitination, preventing their degradation and thus affecting the functional role of SEL-10. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A has been reported to disrupt proteasomal activity. By inhibiting the proteasome, Withaferin A can indirectly inhibit SEL-10's function by causing an accumulation of substrates that SEL-10 would normally target for degradation. | ||||||