Seipin Activators
Seipin activators constitute a chemical class of compounds that possess the capability to indirectly modulate the activity of Seipin, also known as BSCL2 (Berardinelli-Seip congenital lipodystrophy 2). Seipin plays a critical role in cellular lipid metabolism and lipid droplet formation, serving as a key regulator of these processes.
One category of Seipin activators includes phospholipid synthesis enhancers such as Phosphatidylcholine, which can enhance phospholipid biosynthesis, providing essential components required for lipid droplet formation. This indirect activation of Seipin promotes its role in facilitating lipid metabolism and lipid droplet biogenesis. Additionally, Seipin can be influenced by AMPK (AMP-activated protein kinase) activators like AICAR, which regulate cellular energy status and lipid metabolism. By activating AMPK, these compounds indirectly impact Seipin, potentially modulating lipid droplet formation and lipid metabolism processes. Other Seipin activators involve fatty acid modulators, ER stress inducers, lipase inhibitors, PPAR agonists, autophagy modulators, calcium ionophores, lipid transport enhancers, ER modulators, and protein kinase inhibitors, each exerting their effects on cellular lipid homeostasis, lipid droplet dynamics, and Seipin regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Enhances phospholipid synthesis, indirectly activating Seipin by providing essential components for lipid droplet formation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, indirectly influencing Seipin by regulating cellular energy status and lipid metabolism, potentially affecting lipid droplet formation. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Modulates fatty acid metabolism, indirectly impacting Seipin since its function is tied to the regulation of fatty acid storage and lipid droplet formation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Is a PPARγ agonist that can indirectly impact Seipin by regulating genes involved in lipid metabolism and lipid droplet formation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Can modulate autophagy and indirectly affect Seipin by influencing the degradation and turnover of lipid droplets. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Disrupts calcium homeostasis and can indirectly impact Seipin since calcium signaling is involved in lipid metabolism and droplet formation. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Inhibits AMPK, which can indirectly affect Seipin, as AMPK is involved in lipid metabolism and droplet regulation within cells. | ||||||