Sec24B Activators
Sec24B Activators are a group of chemical compounds that facilitate the functional activity of Sec24B through several distinct but related signaling pathways. Forskolin, by increasing intracellular cAMP, engages protein kinase A (PKA) to phosphorylate targets that are crucial for the COPII vesicle formation, thereby enhancing the role Sec24B plays in this process. Similar indirect mechanisms are employed by Phorbol 12-myristate 13-acetate (PMA) and Ionomycin, which activate PKC and increase intracellular calcium levels, respectively, each leading to the activation of kinases that can phosphorylate and regulate proteins involved in the trafficking process that relies on Sec24B. Epigallocatechin gallate (EGCG) furthers the activity of Sec24B by inhibiting kinases that would otherwise phosphorylate and inhibit proteins crucial for COPII vesicle formation, while LY294002 and U0126 selectively inhibit PI3K and MEK1/2, respectively, to modulate the phosphorylation landscape in favorof Sec24B's function.
The lipid signaling molecule Sphingosine-1-phosphate can activate G-protein coupled receptors to initiate a cascade that ends with the phosphorylation of COPII components, enhancing Sec24B's role in vesicle formation. Thapsigargin and A23187 both perturb calcium homeostasis, each leading to enhanced Sec24B activity by initiating calcium-dependent signaling that is likely to converge on the phosphorylation of Sec24B-related proteins within the COPII pathway. Staurosporine and Genistein offer a strategic inhibition of kinases that negatively regulate COPII vesicle formation, thus indirectly augmenting Sec24B's activity by lifting inhibitory signals. Similarly, SB203580's inhibition of p38 MAPK shifts the balance of cellular phosphorylation processes, favoring those that activate Sec24B and enhance its role in vesicle trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly elevates intracellular cAMP levels, which can enhance the activity of Sec24B through PKA activation. The increase in cAMP would lead to PKA-mediated phosphorylation events that can facilitate the coat protein complex II (COPII) vesicle formation, a process that Sec24B is integral to. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, as a potent activator of protein kinase C (PKC), indirectly enhances Sec24B activity by promoting phosphorylation of proteins involved in the COPII vesicle formation pathway, where Sec24B functions as a component for vesicle budding. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin, a calcium ionophore, increases intracellular calcium levels, potentially enhancing the activity of Sec24B by stimulating calcium-dependent kinases that phosphorylate components of the COPII vesicle formation pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, known for its inhibitory effect on various kinases, may enhance Sec24B activity by reducing inhibitory phosphorylation of proteins that interact with Sec24B, thus promoting efficient COPII vesicle formation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, as a PI3K inhibitor, can enhance Sec24B activity indirectly by modulating phosphorylation cascades that influence the assembly of the COPII complex, hence promoting the vesicular trafficking process that Sec24B is a part of. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can enhance Sec24B activity by acting through G-protein coupled receptors to stimulate downstream kinases that phosphorylate proteins in the COPII vesicle formation pathway. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin elevates cytosolic calcium by blocking the ER calcium ATPase, potentially enhancing Sec24B activity by activating calcium-dependent kinases that facilitate COPII vesicle formation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, another calcium ionophore, can enhance Sec24B activity by increasing intracellular calcium levels, thus possibly stimulating kinases that phosphorylate COPII components and enhance vesicle formation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, a kinase inhibitor, could potentially enhance Sec24B function by specifically inhibiting kinases that negatively regulate COPII vesicle formation, thereby promoting Sec24B’s role in this process. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, as a tyrosine kinase inhibitor, could enhance Sec24B activity by reducing competitive phosphorylation that might otherwise inhibit the proteins involved in the COPII vesicle formation pathway. | ||||||