SEC24A Activators
SEC24A Activators are a class of chemical compounds that primarily target SEC24A, a protein involved in the early stages of protein trafficking within cells. These activators play a crucial role in regulating intracellular protein transport, a fundamental process essential for the proper functioning of eukaryotic cells. SEC24A, a component of the COPII vesicle coat complex, functions as a cargo receptor, selectively packaging specific proteins into transport vesicles originating from the endoplasmic reticulum (ER). The activation of SEC24A is pivotal for ensuring the efficient and accurate sorting of proteins destined for various cellular destinations.
SEC24A are designed to modulate its activity, enhancing or fine-tuning its role in protein transport. By interacting with SEC24A, they can influence the selection of cargo proteins for packaging into transport vesicles, thereby impacting the flow of proteins through the secretory pathway. This class of compounds is of significant interest to cell biologists and researchers studying intracellular protein trafficking, as it provides a means to investigate and manipulate this essential cellular process. Understanding how SEC24A activators work and their effects on protein transport can shed light on the mechanisms underlying various cellular functions and may have implications in fields such as cell biology and molecular biology research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Activates SEC24A by promoting the phosphorylation of specific residues on SEC24A, enhancing its interaction with cargo proteins and facilitating protein transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Indirectly activates SEC24A by inhibiting ADP-ribosylation factor (ARF), leading to the disruption of COPI-coated vesicle formation and the activation of SEC24A-mediated protein transport. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Facilitates SEC24A activation by disrupting the pH gradient across the Golgi apparatus, leading to the accumulation of cargo proteins in the Golgi and their subsequent recognition and transport by SEC24A. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Activates SEC24A by binding to specific cargo proteins, promoting their packaging into COPII-coated vesicles for transport from the endoplasmic reticulum to the Golgi apparatus. | ||||||
Digitonin | 11024-24-1 | sc-280675A sc-280675 sc-280675B sc-280675C sc-280675D sc-280675E | 100 mg 250 mg 1 g 2.5 g 5 g 10 g | $84.00 $180.00 $385.00 $935.00 $1679.00 $2929.00 | 10 | |
Indirectly activates SEC24A by disrupting cholesterol-rich membrane microdomains, facilitating the recruitment of cargo proteins to SEC24A-coated vesicles for transport. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Stimulates SEC24A activation by inducing calcium release from the endoplasmic reticulum, leading to calcium-dependent activation of SEC24A-mediated protein transport. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $21.00 $65.00 $120.00 $251.00 $815.00 | 23 | |
Indirectly activates SEC24A by chelating calcium ions, leading to the disruption of calcium-dependent inhibition of SEC24A-mediated protein transport from the endoplasmic reticulum. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Enhances SEC24A activation by inhibiting protein kinase C (PKC), relieving its negative regulation on SEC24A-mediated vesicle formation and promoting cargo protein transport. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Activates SEC24A by inhibiting protein tyrosine phosphatases (PTPs), leading to increased phosphorylation of SEC24A and enhancement of its activity in cargo protein transport. | ||||||