SEC24A Antibody (4D9): sc-517155

SEC24A Antibody (4D9) is a mouse monoclonal IgG2a kappa light chain antibody that detects SEC24A protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SEC24A antibody (4D9) is available as a non-conjugated format. SEC24A, or SEC24 family member A, is a 1,093 amino acid protein that plays a crucial role in vesicle trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus, which is essential for proper secretion of proteins and lipids in eukaryotic cells. SEC24A is part of the Sec24 subfamily within the larger Sec23/Sec24 protein family, which is vital for the formation of COPII-coated vesicles that transport cargo from the ER. SEC24A is one of four mammalian homologs, including SEC24B, SEC24C, and SEC24D, that are closely related to the yeast protein Sec24, a key component of the COPII complex. The COPII complex is responsible for selective export of membrane proteins, and SEC24A functions as a critical component of this machinery, ensuring efficient transport of secretory proteins to the Golgi apparatus. Localized in the cytoplasm, SEC24A is expressed in various cell types, including fibroblasts, hepatocytes, and lymphocytes, and has the ability to form heterodimers with SEC24B and SEC24C, further enhancing functional versatility. Additionally, SEC24A exists as two alternatively spliced isoforms, which may contribute to regulatory mechanisms in vesicle trafficking.

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SEC24A Antibody (4D9) References:

1. Sec24 proteins and sorting at the endoplasmic reticulum.  |  Pagano, A., et al. 1999. J Biol Chem. 274: 7833-40. PMID: 10075675
2. A family of mammalian proteins homologous to yeast Sec24p.  |  Tang, BL., et al. 1999. Biochem Biophys Res Commun. 258: 679-84. PMID: 10329445
3. Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum.  |  Wendeler, MW., et al. 2007. EMBO Rep. 8: 258-64. PMID: 17255961
4. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope.  |  Mancias, JD. and Goldberg, J. 2007. Mol Cell. 26: 403-14. PMID: 17499046
5. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.  |  Mancias, JD. and Goldberg, J. 2008. EMBO J. 27: 2918-28. PMID: 18843296
6. GNOM-LIKE1/ERMO1 and SEC24a/ERMO2 are required for maintenance of endoplasmic reticulum morphology in Arabidopsis thaliana.  |  Nakano, RT., et al. 2009. Plant Cell. 21: 3672-85. PMID: 19933201
7. A missense mutation in the Arabidopsis COPII coat protein Sec24A induces the formation of clusters of the endoplasmic reticulum and Golgi apparatus.  |  Faso, C., et al. 2009. Plant Cell. 21: 3655-71. PMID: 19933202
8. Selective export of human GPI-anchored proteins from the endoplasmic reticulum.  |  Bonnon, C., et al. 2010. J Cell Sci. 123: 1705-15. PMID: 20427317

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SEC24A Antibody (4D9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SEC24A Antibody (4D9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SEC24A Antibody (4D9) Specifications

Alternate Product Name: SEC24A

Product Clone Name: 4D9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 301-390

Epitope Target: SEC24A

Epitope Species: human

Product Reactivity/Detection: SEC24A

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SEC24A Antibody (4D9): N/A