SDHC Inhibitors

The class of SDHC inhibitors encompasses chemicals that indirectly affect the function of SDHC by targeting the SDH complex or associated metabolic and electron transport pathways. SDHC forms a part of the SDH complex, which is integral to both the TCA cycle and the mitochondrial electron transport chain. Inhibition of SDHC, and thereby the SDH complex, can significantly impact cellular metabolism and energy production. Inhibitors such as Malonate and 3-Nitropropionic acid directly target the SDH complex. Malonate acts as a competitive inhibitor, while 3-Nitropropionic acid is an irreversible inhibitor. These compounds can affect the function of SDHC by inhibiting the overall activity of the SDH complex, leading to disruptions in the TCA cycle and electron transport chain. Thenoyltrifluoroacetone (TTFA) is another notable inhibitor, specifically targeting complex II of the electron transport chain, where SDHC is located. By inhibiting complex II, TTFA affects the electron transfer process and disrupts mitochondrial respiration. Atpenin A5 also specifically targets the SDH complex, providing a more direct approach to inhibiting SDHC's function. Additionally, compounds like Itaconate, which is an endogenous metabolite, and Carboxin, primarily used as a fungicide, have been shown to inhibit the SDH complex. Their effects on SDHC offer insights into metabolic regulation. Other inhibitors listed, such as Phenylarsine oxide, Sodium azide, Antimycin A, Rotenone, and Oligomycin, target various components of the mitochondrial electron transport chain or mitochondrial enzymes. While these do not directly inhibit SDHC, their action can indirectly impact the function of the SDH complex by altering mitochondrial activity and cellular energy metabolism.