SCAMP5 Activators
CAMP5 Activators are a group of chemical compounds that have garnered significant attention in the field of molecular biology and cellular research. These activators are primarily characterized by their ability to modulate the activity of SCAMP5, a protein that plays a crucial role in intracellular membrane trafficking and vesicle formation. SCAMP5, or Secretory Carrier Membrane Protein 5, is a member of the SCAMP family of proteins that are found in various eukaryotic cells, including neurons and other secretory cells. SCAMP5 is primarily localized in the trans-Golgi network and post-Golgi vesicles, and it has been implicated in the regulation of vesicle transport and exocytosis.
SCAMP5 Activators has opened up new avenues for research into the intricate mechanisms underlying intracellular membrane dynamics. These compounds are designed to specifically interact with SCAMP5, leading to alterations in its function. As a result, SCAMP5 Activators have been instrumental in elucidating the role of SCAMP5 in vesicle trafficking, exocytosis, and other cellular processes. Researchers have used these activators to study the dynamics of membrane-bound organelles, protein trafficking, and the release of cellular contents. Their use has provided valuable insights into the fundamental processes that govern cellular communication and secretion.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA functions as a potent activator of protein kinase C (PKC). PKC, in turn, can phosphorylate a wide range of substrates, potentially including SCAMP5, leading to its enhanced functional activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular cAMP levels. Elevated cAMP may activate PKA, which could phosphorylate SCAMP5 or associated regulatory proteins, thus enhancing SCAMP5 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Increased calcium can activate calcium-dependent kinases that may phosphorylate SCAMP5 or affect its activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA may enhance SCAMP5 function through phosphorylation or regulation of its membrane trafficking activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of proteins. This inhibition may result in enhanced phosphorylation and activation of SCAMP5. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is also an inhibitor of protein phosphatases such as PP1 and PP2A. By inhibiting dephosphorylation, it could maintain SCAMP5 in a phosphorylated and active state. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to inhibit certain types of kinases, potentially altering the phosphorylation status of proteins in signaling pathways that include SCAMP5, thereby indirectly increasing its activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates MAPK pathways. This activation could lead to the phosphorylation of SCAMP5 or associated regulatory proteins, enhancing SCAMP5 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to increased cytosolic calcium levels. Elevated calcium can activate kinases that may enhance SCAMP5 activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is another cAMP analog that can permeate cell membranes and activate PKA. PKA activation can lead to the phosphorylation and potential enhancement of SCAMP5 activity. | ||||||