SBNO1 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the Strawberry Notch Homolog 1 (SBNO1) protein. The SBNO1 protein, also known as Strawberry Notch (Sbno) in Drosophila, is a conserved signaling factor that plays a crucial role in various cellular processes, including embryonic development and immune response. The development of SBNO1 inhibitors stems from the recognition of the protein's involvement in signal transduction pathways and its potential significance in regulating gene expression. These inhibitors are meticulously designed molecules that interfere with the enzymatic or functional activity of SBNO1, thereby influencing downstream cellular responses.
SBNO1 inhibitors are often tailored to interact specifically with the active sites or binding domains of the SBNO1 protein. Rational drug design approaches, including structure-activity relationship studies, computational modeling, and high-throughput screening, contribute to the identification and optimization of these inhibitors. By selectively modulating SBNO1, these inhibitors provide researchers with valuable tools to investigate the intricacies of cellular processes governed by SBNO1, unraveling its specific functions within signaling cascades. The ongoing research in this field aims to deepen our understanding of the molecular mechanisms orchestrated by SBNO1, shedding light on its diverse roles in cellular physiology and potentially uncovering novel avenues for further exploration in basic biological research.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
WZ4003 is a selective inhibitor of NUAK family kinase 1 and 2, which are downstream effectors in the SBNO1 pathway, thereby reducing SBNO1 activity indirectly by modulating the kinases that regulate it. | ||||||
PF-3758309 | 898044-15-0 | sc-478493 | 10 mg | $260.00 | ||
PF-3758309 is a potent inhibitor of PAK4, a kinase that interacts with several signaling pathways including those where SBNO1 is implicated, leading to a decrease in SBNO1-mediated effects. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor which can impact pathways associated with SBNO1, particularly in the context of transcriptional regulation and cytoskeletal arrangement. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is a JNK inhibitor that can modulate the activity of transcription factors and signalling pathways involving SBNO1, altering its functional outcomes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can alter the signaling cascades related to SBNO1's role in immune response regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can affect various signaling pathways including those where SBNO1 may play a role, leading to altered SBNO1 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor which can indirectly influence SBNO1 activity by altering the ERK pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of signaling pathways that can intersect with those involving SBNO1, possibly affecting its role in these pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor with the capacity to disrupt signaling pathways that SBNO1 may be part of, thus altering its function indirectly. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
ZM336372 is a CRAF inhibitor that can modulate the MAPK pathway, which may have implications for SBNO1's activity in signaling cascades. |