SART2 Activators
SART2 Activators are a series of chemical compounds that indirectly influence the functional activity of SART2 through modulation of specific signaling pathways and cellular processes. Forskolin, by increasing cAMP levels, indirectly activates SART2 by enabling PKA to phosphorylate target proteins that interact with SART2, thereby enhancing its cellular signaling role. Ionomycin and A23187, as calcium ionophores, could increase intracellular calcium, potentially activating calcium-dependent kinases that may phosphorylate and enhance the activity of SART2. PMA, as a PKC activator, may promote phosphorylation within the SART2 pathway, and Sildenafil, by inhibiting PDE5, prevents the breakdown of cGMP, which could intensify SART2 activity through cGMP-dependent protein kinases.
Moreover, EGCG, by inhibiting certain kinases, might reduce negative regulation of SART2, thus indirectly enhancing its activity. Thapsigargin, by disrupting calcium homeostasis, and NAD+, as a redox cofactor, are also implicated in modulating pathways that interact with SART2, suggesting an enhancement of its activity. Lastly, Isoproterenol, by stimulating beta-adrenergic receptors to increase cAMP, could further promote SART2 activity through cAMP-dependent pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, leading to increased levels of cAMP. Elevated cAMP activates PKA, which could phosphorylate SART2, enhancing its activity in cell signaling. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, possibly activating calcium-dependent proteins that interact with SART2, thus enhancing its function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator that mimics diacylglycerol. PKC activation may lead to phosphorylation of proteins in the SART2 pathway, enhancing SART2 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a kinase inhibitor that might block kinases that negatively regulate SART2, thereby enhancing SART2 activity indirectly. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis, potentially enhancing calcium-mediated signaling pathways that could indirectly increase SART2 activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in redox reactions and may modulate signaling pathways that include SART2, potentially enhancing its activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore like ionomycin and may similarly enhance SART2's function by increasing intracellular calcium. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels, potentially enhancing SART2 activity through cAMP-dependent pathways. | ||||||