SARM Activators
SARM1, also known as Sterile alpha and TIR motif-containing 1, is an essential protein with significant roles in both innate immune signaling and neuronal survival. This protein integrates into multiple cellular processes and pathways, making its activity complex and multifaceted.
LPS (Lipopolysaccharide) is one such agent that can activate Toll-like receptors, ushering SARM1's involvement in immune signaling. Similarly, Poly(I:C), a synthetic analog of double-stranded RNA, can stimulate pathways wherein SARM1 may participate. Further, agents like Imiquimod and Resiquimod, recognized as Toll-like receptor 7 agonists, trigger pathways where SARM1 plays a pivotal role. These chemicals, along with Pam3CSK4, serve as key contributors to the activation of their respective Toll-like receptors, which are integral in innate immune signaling. The subsequent signaling cascades can engage SARM1 indirectly, establishing a network of interwoven cellular processes. R848, also known as Resiquimod, along with other agents like CL075, Gardiquimod, CL097, and TDB, further contribute to this intricate interplay by activating different Toll-like receptors and thus potentially influencing SARM1's activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS can activate Toll-like receptors, potentially leading to SARM1 involvement in immune signaling. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
A synthetic analog of double-stranded RNA, which might stimulate pathways involving SARM1. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
A Toll-like receptor 7 agonist that can trigger pathways where SARM1 may play a role. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
Another TLR7 agonist, it might indirectly affect SARM1 via innate immune signaling. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
TLR1/TLR2 agonist that might indirectly engage SARM1 through immune pathway activation. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $157.00 $282.00 $516.00 $1177.00 $20138.00 $32779.00 $70753.00 | 1 | |
A TLR7-specific agonist that might indirectly modulate SARM1 activity. | ||||||
CL097 | 1026249-18-2 | sc-507394 | 5 mg | $135.00 | ||
TLR7/8 agonist that can influence innate immune pathways potentially connected to SARM1. | ||||||