Molecular structure of CL097, CAS Number: 1026249-18-2
CL097 (CAS 1026249-18-2)
Alternate Names:
2-(ethoxymethyl)-3H-imidazo[4,5-c]quinolin-4-amine
CAS Number:
1026249-18-2
Molecular Weight:
242.3
Molecular Formula:
C13H14N4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
CL097 (CAS 1026249-18-2) References
- CL097, a TLR7/8 ligand, inhibits TLR-4--dependent activation of IRAK-M and BCL-3 expression. | Petricevic, B., et al. 2009. Shock. 32: 484-90. PMID: 19333135
- Interferon-α suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist. | Tajuddin, T., et al. 2010. J Gastroenterol Hepatol. 25: 1883-90. PMID: 21092001
- Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse. | Lee, AS., et al. 2011. Diabetologia. 54: 1407-16. PMID: 21340621
- The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. | Makni-Maalej, K., et al. 2012. J Immunol. 189: 4657-65. PMID: 23002436
- Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production. | Lee, J., et al. 2015. PLoS One. 10: e0123165. PMID: 25875128
- K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. | Groß, CJ., et al. 2016. Immunity. 45: 761-773. PMID: 27692612
- Immunization with glypican-3 nanovaccine containing TLR7 agonist prevents the development of carcinogen-induced precancerous hepatic lesions to cancer in a murine model. | Chen, K., et al. 2018. Am J Transl Res. 10: 1736-1749. PMID: 30018715
- pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG. | Wu, J., et al. 2019. J Immunol Res. 2019: 1749803. PMID: 31093508
- Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles. | Kaushik, D., et al. 2021. RSC Med Chem. 12: 1065-1120. PMID: 34355178
- Sex-dependent differences in type I IFN-induced natural killer cell activation. | Pujantell, M., et al. 2023. Front Immunol. 14: 1277967. PMID: 38162640
Activator of:
CLEC-9A, DDX60L, IFN-β, IL-TIFb, MDA5, MIP-5, MyD88, SARM, TIM-4, TLR3, TLR8, TMEM143, and UNC93B1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CL097, 5 mg | sc-507394 | 5 mg | $135.00 |