SARA Inhibitors
SARA inhibitors, short for Smad Anchor for Receptor Activation inhibitors, are a class of chemical compounds that play a crucial role in the regulation of cellular signaling pathways, particularly in the context of the transforming growth factor-beta (TGF-β) signaling pathway. This class of compounds targets a specific protein called Smad Anchor for Receptor Activation (SARA) and modulates its function. SARA is an essential component of the TGF-β signaling cascade, which is involved in various cellular processes, including cell growth, differentiation, and apoptosis. SARA inhibitors are designed to interfere with the interactions between SARA and its binding partners, disrupting the transmission of signals downstream of the TGF-β receptor.
The mechanism of action of SARA inhibitors primarily involves binding to SARA and preventing its association with the TGF-β receptor complex. This interference inhibits the recruitment of downstream signaling molecules, such as Smad proteins, to the receptor complex, ultimately dampening the activation of the TGF-β pathway. By doing so, SARA inhibitors can exert control over various cellular processes influenced by TGF-β signaling. These compounds are of particular interest in the field of cellular biology and signal transduction research, as they provide valuable tools for investigating the intricacies of the TGF-β pathway and its implications in normal development and disease states.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is a well-known SARA inhibitor that acts by blocking the TGF-β receptor, thereby inhibiting the downstream signaling pathways, including SARA. | ||||||
ALK5 Inhibitor II | 446859-33-2 | sc-221234 sc-221234A sc-221234B sc-221234C sc-221234D sc-221234E sc-221234F | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $77.00 $153.00 $219.00 $663.00 $1248.00 $4382.00 $7850.00 | 8 | |
ALK5 Inhibitor II is a small molecule inhibitor of TGF-β type I receptor (ALK5), which is involved in the activation of SARA. | ||||||
LY2109761 | 700874-71-1 | sc-396262 sc-396262A | 1 mg 5 mg | $89.00 $275.00 | 9 | |
LY2109761 is an ATP-competitive inhibitor of TGF-β type I receptor kinase activity, effectively suppressing TGF-β signaling and SARA activation. | ||||||
LY2157299 | 700874-72-2 | sc-391123 sc-391123A | 5 mg 10 mg | $213.00 $359.00 | 3 | |
LY2157299 is a TGF-β receptor inhibitor that can modulate SARA activity. | ||||||
GW788388 | 452342-67-5 | sc-363544 sc-363544A | 5 mg 25 mg | $95.00 $384.00 | ||
GW788388 is a selective inhibitor of the TGF-β type I receptor and can indirectly influence SARA function. | ||||||
TGF-β RI Kinase Inhibitor V | 627536-09-8 | sc-203294 | 2 mg | $88.00 | 3 | |
Also called SD-208, this compound is an ATP-competitive inhibitor of the TGF-β type I receptor kinase and, as a result, can inhibit SARA-dependent signaling. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
LY364947 is an inhibitor of the TGF-β type I receptor kinase and is used in research to study SARA-dependent signaling pathways. | ||||||
SB-505124 | 694433-59-5 | sc-362794 sc-362794A | 10 mg 50 mg | $327.00 $1377.00 | 2 | |
SB505124 is a potent inhibitor of TGF-β type I receptor kinase, and it can be employed to inhibit SARA-associated TGF-β signaling. | ||||||