SAP 62 Activators
SF3A2 activators comprise a series of chemical compounds that indirectly stimulate the functional activity of SF3A2 by modulating the spliceosome, the complex within which SF3A2 operates. Adenosine Triphosphate (ATP) is fundamental for spliceosome assembly and function, providing the energy required for the splicing process and enabling SF3A2 to perform its role effectively. Similarly, Magnesium Chloride (MgCl2) supplies Mg2+ ions that stabilize the spliceosome structure, facilitating SF3A2's activity in catalyzing the splicing reaction.SF3A2 Activators are a category of chemical compounds that play a crucial role in regulating cellular processes at the molecular level. These activators are known for their ability to modulate the activity of the SF3A2 protein, which is an integral component of the spliceosome machinery in eukaryotic cells. The spliceosome is responsible for the intricate process of RNA splicing, where non-coding introns are removed from precursor mRNA molecules, and exons are ligated together to form mature mRNA strands. SF3A2, as a core component of the spliceosome, participates in the recognition and binding of splice sites on pre-mRNA, ensuring accurate and precise splicing. SF3A2 Activators are compounds that interact with SF3A2, altering its conformation or activity to influence the splicing process, thus impacting gene expression and protein production within the cell.
SF3A2 activity by these activators is of great significance in cellular biology, as it can have far-reaching effects on gene expression and, consequently, the functional diversity of proteins produced within the cell. These activators may serve as invaluable tools for researchers studying the intricate world of RNA splicing and gene regulation, shedding light on the underlying mechanisms that govern these processes. Understanding the role of SF3A2 Activators in the context of splicing can provide insights into how cells finely tune gene expression, adapt to different environmental conditions, and respond to various stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP provides the necessary energy for the spliceosome assembly, where SF3A2 is a critical component. The hydrolysis of ATP is essential for the conformational changes and rearrangements within the spliceosome complex, thus indirectly enhancing the activity of SF3A2. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Mg2+ ions are crucial for stabilizing the structure of the spliceosome and are required for catalysis of the splicing reaction. Mg2+ binding enhances the functionality of the spliceosome, thus playing a role in the activation of SF3A2 within this complex. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe is a methyl donor in various biochemical reactions, including RNA methylation. Since methylation can impact RNA splicing, SAMe indirectly affects the splicing process in which SF3A2 is involved, potentially enhancing its role in spliceosome function. | ||||||
2′-Deoxyadenosine 5′-triphosphate disodium salt | 74299-50-6 | sc-209372 sc-209372A sc-209372B sc-209372C sc-209372D | 10 mg 100 mg 250 mg 1 g 5 g | $90.00 $208.00 $416.00 $1022.00 $4058.00 | ||
dATP can be incorporated into RNA during the spliceosome-mediated splicing reaction. Its presence can enhance the efficiency of the splicing process in which SF3A2 is a key component, thus indirectly activating SF3A2 function. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $88.00 $120.00 | 2 | |
UTP is a precursor in the synthesis of RNA. By increasing the pool of UTP, the synthesis of pre-mRNA transcripts is enhanced, indirectly increasing the requirement for splicing and potentially the activity of SF3A2 in the spliceosome complex. | ||||||
Ammonium Sulfate | 7783-20-2 | sc-29085A sc-29085 sc-29085B sc-29085C sc-29085D sc-29085E | 500 g 1 kg 2 kg 5 kg 10 kg 22.95 kg | $11.00 $21.00 $31.00 $41.00 $61.00 $102.00 | 9 | |
Ammonium sulfate is used to fractionate proteins by precipitation. Precipitating spliceosomal components can concentrate the spliceosome complex and thereby potentially increase the functional activity of SF3A2 in pre-mRNA splicing. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can affect multiple signaling pathways, including the inhibition of phosphodiesterases, which increases cAMP levels. Elevated cAMP may enhance splicing efficiency by modulating spliceosome assembly and activity, indirectly affecting SF3A2's function. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
NaCl at moderate concentrations can stabilize the spliceosome complex by shielding negative charges, potentially enhancing the activity of SF3A2 by improving splicing efficiency. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions are important for the structural integrity of many protein complexes. While not directly involved in splicing, zinc may stabilize the spliceosome assembly, indirectly supporting the functional activity of SF3A2. | ||||||
Glycerol | 56-81-5 | sc-29095A sc-29095 | 100 ml 1 L | $56.00 $153.00 | 12 | |
Glycerol is used as a stabilizing agent in protein storage and can preserve the activity of the spliceosome complex. The presence of glycerol may indirectly enhance the activity of SF3A2 by maintaining the integrity of the spliceosome during splicing. | ||||||