SAA4 Activators
Serum Amyloid A4 (SAA4) can influence its function through various mechanisms, primarily by modulating pathways that enhance the cell's ability to respond to oxidative stress and inflammation. Curcumin, sulforaphane, tert-butylhydroquinone (TBHQ), silymarin, kaempferol, and oltipraz all activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which can upregulate the antioxidant response within cells. Activation of Nrf2 leads to the expression of detoxifying enzymes, promoting an intracellular environment that supports the activation of SAA4. This process is crucial as SAA4 is an acute-phase protein, and its functional activity is often associated with managing oxidative stress and inflammation.
Resveratrol, by activating SIRT1, and alpha-lipoic acid, by increasing levels of glutathione and also activating Nrf2, contribute to the regulation of inflammation and stress resistance, which can create favorable conditions for SAA4 activation. Quercetin's interaction with AMP-activated protein kinase (AMPK) supports the cellular energy homeostasis, which is beneficial for SAA4's role in lipid metabolism and transport, particularly during acute-phase responses. Genistein's ability to activate estrogen receptors can foster an anti-inflammatory environment, which is conducive for SAA4 activity. Tocotrienols, part of the vitamin E family, are known for their role in lipid metabolism and their antioxidant potential through Nrf2 activation, which could also facilitate the activation of SAA4. Collectively, these chemicals can enhance the functional activity of SAA4 by promoting antioxidant defenses and managing the cellular response to inflammation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is a key regulator of the antioxidant response and induces the expression of detoxifying enzymes. SAA4 is an acute-phase protein with potential antioxidant properties. Activation of Nrf2 by curcumin could enhance SAA4 activation by bolstering its antioxidant role. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which is involved in the regulation of inflammation and stress resistance. SAA4, being part of the acute-phase response, may be upregulated by SIRT1 activity due to enhanced cellular resilience to inflammatory stress, thereby promoting SAA4 activation as part of the response to cellular stress and inflammation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane also activates Nrf2, promoting antioxidant response elements and enhancing cellular defense mechanisms. As SAA4 has a role in the acute phase response, its functional activity could be increased as part of the broader cellular defense mechanism orchestrated by Nrf2, thus sulforaphane can activate SAA4 by enhancing the cellular antioxidant capacity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates AMP-activated protein kinase (AMPK), which plays a role in cellular energy homeostasis. The activation of AMPK may induce a favorable environment for the functional activation of SAA4 during metabolic stress, as SAA4 is involved in lipid metabolism and transport during the acute-phase response. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is known to increase the levels of glutathione and to activate Nrf2, leading to an upregulation of the body's antioxidant defenses. As SAA4 is involved in the acute phase response, its activation is likely supported by the improved antioxidant status of the cell, which alpha-lipoic acid can provide. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates Nrf2 signaling, which upregulates the expression of phase II detoxifying enzymes. SAA4, being an acute-phase protein, could have its functional activation enhanced by the overall increase in cellular protective enzymes, as it may play a role in neutralizing oxidative stress products during the acute-phase response. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates estrogen receptors, which can lead to anti-inflammatory responses. Given the role of SAA4 in the immune system and inflammation, activation of estrogen receptors by genistein could support the anti-inflammatory environment that facilitates the functional activation of SAA4. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
TBHQ is a known activator of Nrf2, which leads to enhanced expression of enzymes involved in the oxidative stress response. Through this pathway, TBHQ activation of Nrf2 could support the activation of SAA4, as it may be involved in the management of oxidative stress during inflammation. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
Silymarin is known to activate Nrf2, which can lead to an increase in cellular antioxidant enzymes. SAA4 activation could be enhanced as part of the cellular defense mechanism against oxidative stress, with silymarin providing the necessary activation of Nrf2 to support this process. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol activates Nrf2 and has anti-inflammatory properties. By activating Nrf2, kaempferol could indirectly activate SAA4 by promoting an anti-inflammatory and antioxidative environment, which could be beneficial for SAA4's function as part of the acute-phase response. | ||||||