SAA1 Activators
SAA1, or Serum Amyloid A1, is an acute-phase protein primarily produced by the liver in response to inflammatory stimuli. Its expression can be induced by proinflammatory cytokines such as IL-1, IL-6, and TNF-α. SAA1 can replace apolipoprotein A1 as the primary apolipoprotein on HDL particles and can affect HDL's functional properties. It also has other biological roles, including recruiting immune cells to inflammatory sites and inducing enzyme secretion from neutrophils.
Activators, in the general context of molecular biology and biochemistry, are compounds or factors that increase the activity or expression of a protein or enzyme. In the context of SAA1, activators would be expected to increase the expression or activity of the SAA1 protein. Mechanistically, activators can work at multiple levels, such as by binding directly to the protein, modifying its structure to a more active form, or by influencing the transcription or translation processes that produce the protein. Identifying and understanding the function of such activators would be crucial in providing insights into the complex regulatory networks governing inflammatory responses in the body.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A metabolite, can modulate gene expression and has been observed to increase SAA1 levels in specific studies. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a protein kinase C activator which can stimulate the production of inflammatory mediators, potentially leading to increased SAA1 synthesis. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Ceramides are lipid signaling molecules known to participate in stress responses and inflammation, possibly inducing SAA1 expression. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic acid can cause cellular stress, which might activate inflammatory pathways that lead to elevated SAA1 levels. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly(I:C) is an analog of viral double-stranded RNA, which can activate innate immune responses, including the production of SAA1. | ||||||
b-Glucan, Saccharomyces cerevisiae | 9012-72-0 | sc-203832 | 25 mg | $307.00 | ||
Beta-glucan, a polysaccharide found in the cell walls of fungi and some plants, can stimulate immune responses leading to increased SAA1 expression. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic acid, a saturated fatty acid, has been associated with inflammation and may contribute to enhanced SAA1 levels. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a cellular messenger that can modulate numerous cellular pathways, and its presence may result in elevated SAA1 expression in certain conditions. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid, produced in the colon by bacterial fermentation, possesses anti-inflammatory properties and might upregulate SAA1. | ||||||
Lipoteichoic acid | 56411-57-5 | sc-507479 | 5 mg | $248.00 | ||
Lipoteichoic acid, found in the cell walls of Gram-positive bacteria, can stimulate the immune system and potentially elevate SAA1 levels. | ||||||