Date published: 2025-10-17

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RyR Antibodies

Santa Cruz Biotechnology delivers a wide array of RyR monoclonal antibodies for advanced research in muscle physiology and cellular signaling. RyR Antibodies are compatible with western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Ryanodine receptors (RyRs) play a crucial role in calcium release from the sarcoplasmic reticulum, which is essential for muscle contraction and various cellular processes. Dysregulation of RyR function has been implicated in several diseases, including cardiac and skeletal muscle disorders, making research in this area critical for understanding these pathologies. By studying the interactions and functions of ryanodine receptors, researchers can gain insights into fundamental biological mechanisms and potential therapeutic targets. RyR monoclonal antibodies enable precise detection and characterization of specific protein variants, supporting detailed analysis of their distribution and function in different tissues. Understanding the role of ryanodine receptors in calcium signaling pathways has significant implications for developing targeted therapies for muscle-related disorders. Santa Cruz Biotechnology monoclonal antibodies for RyR research empower scientists to advance their understanding of muscle biology and contribute to breakthrough discoveries in therapeutic development.

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RyR Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

RyR Antibody (F-1)

sc-376507mouse IgG1 κ1-300 (h)WB, IP, IF, ELISAm, r, h
10
(9)

RyR-1 Antibody (XA7)

sc-65640mouse IgM(rabbit)WB, IPm, r, rabbit and canine
1
(1)

RyR-1 Antibody (XA7B6)

sc-73607mouse IgM(rabbit)WB, IPm, r, rabbit and canine
1
(1)

RyR-1 Antibody (8.U.100)

sc-71989mouse IgM κ(rabbit)WB, IPm, r, rabbit and canine

new

(1)

RyR CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

RyR-1 CRISPR/Cas9 KO Plasmid (h)

sc-401470hGene KnockoutGFP0
(0)

RyR-1 HDR Plasmid (h)

sc-401470-HDRhHomology Directed RepairPuromycin0
(0)

RyR-1 Double Nickase Plasmid (h)

sc-401470-NIChGene KnockoutPuromycin0
(0)

RyR-1 Double Nickase Plasmid (h2)

sc-401470-NIC-2hGene KnockoutPuromycin0
(0)

RyR-1 CRISPR/Cas9 KO Plasmid (m)

sc-422774mGene KnockoutGFP0
(0)

RyR-1 HDR Plasmid (m)

sc-422774-HDRmHomology Directed RepairPuromycin0
(0)

RyR-1 Double Nickase Plasmid (m)

sc-422774-NICmGene KnockoutPuromycin0
(0)

RyR-1 Double Nickase Plasmid (m2)

sc-422774-NIC-2mGene KnockoutPuromycin0
(0)

RyR-2 CRISPR/Cas9 KO Plasmid (h)

sc-402986hGene KnockoutGFP0
(0)

RyR-2 Double Nickase Plasmid (h)

sc-402986-NIChGene KnockoutPuromycin0
(0)

RyR-2 Double Nickase Plasmid (h2)

sc-402986-NIC-2hGene KnockoutPuromycin0
(0)

RyR-2 CRISPR/Cas9 KO Plasmid (m)

sc-422775mGene KnockoutGFP0
(0)

RyR-2 HDR Plasmid (m)

sc-422775-HDRmHomology Directed RepairPuromycin0
(0)

RyR-2 Double Nickase Plasmid (m)

sc-422775-NICmGene KnockoutPuromycin0
(0)

RyR-2 Double Nickase Plasmid (m2)

sc-422775-NIC-2mGene KnockoutPuromycin0
(0)

RyR-3 CRISPR/Cas9 KO Plasmid (h)

sc-402031hGene KnockoutGFP0
(0)

RyR-3 HDR Plasmid (h)

sc-402031-HDRhHomology Directed RepairPuromycin0
(0)

RyR-3 Double Nickase Plasmid (h)

sc-402031-NIChGene KnockoutPuromycin0
(0)

RyR-3 Double Nickase Plasmid (h2)

sc-402031-NIC-2hGene KnockoutPuromycin0
(0)

RyR-3 CRISPR/Cas9 KO Plasmid (m)

sc-422776mGene KnockoutGFP0
(0)

RyR-3 HDR Plasmid (m)

sc-422776-HDRmHomology Directed RepairPuromycin0
(0)

RyR-3 Double Nickase Plasmid (m)

sc-422776-NICmGene KnockoutPuromycin0
(0)

RyR-3 Double Nickase Plasmid (m2)

sc-422776-NIC-2mGene KnockoutPuromycin0
(0)

RyR CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

RyR CRISPR Activation Plasmid (h)

sc-401470-ACThGene ActivationPuro, Blast, Hygro0
(0)

RyR CRISPR Activation Plasmid (h)

sc-402986-ACThGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 CRISPR Activation Plasmid (h2)

sc-401470-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 Lentiviral Activation Particles (h)

sc-401470-LAChGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 Lentiviral Activation Particles (h2)

sc-401470-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 CRISPR Activation Plasmid (m)

sc-422774-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 CRISPR Activation Plasmid (m2)

sc-422774-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 Lentiviral Activation Particles (m)

sc-422774-LACmGene ActivationPuro, Blast, Hygro0
(0)

RyR-1 Lentiviral Activation Particles (m2)

sc-422774-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 CRISPR Activation Plasmid (h2)

sc-402986-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 Lentiviral Activation Particles (h)

sc-402986-LAChGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 Lentiviral Activation Particles (h2)

sc-402986-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 CRISPR Activation Plasmid (m)

sc-422775-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 CRISPR Activation Plasmid (m2)

sc-422775-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 Lentiviral Activation Particles (m)

sc-422775-LACmGene ActivationPuro, Blast, Hygro0
(0)

RyR-2 Lentiviral Activation Particles (m2)

sc-422775-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 CRISPR Activation Plasmid (h)

sc-402031-ACThGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 CRISPR Activation Plasmid (h2)

sc-402031-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 Lentiviral Activation Particles (h)

sc-402031-LAChGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 Lentiviral Activation Particles (h2)

sc-402031-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 CRISPR Activation Plasmid (m)

sc-422776-ACTmGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 CRISPR Activation Plasmid (m2)

sc-422776-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 Lentiviral Activation Particles (m)

sc-422776-LACmGene ActivationPuro, Blast, Hygro0
(0)

RyR-3 Lentiviral Activation Particles (m2)

sc-422776-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

RyR siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

RyR-1 siRNA (h)

sc-36449hGene SilencingN/A0
(0)

RyR-1 shRNA Plasmid (h)

sc-36449-SHhGene SilencingPuromycin0
(0)

RyR-1 shRNA (h) Lentiviral Particles

sc-36449-VhGene SilencingPuromycin0
(0)

RyR-1 siRNA (m)

sc-36450mGene SilencingN/A0
(0)

RyR-1 shRNA Plasmid (m)

sc-36450-SHmGene SilencingPuromycin0
(0)

RyR-1 shRNA (m) Lentiviral Particles

sc-36450-VmGene SilencingPuromycin0
(0)

RyR-2 siRNA (h)

sc-72012hGene SilencingN/A0
(0)

RyR-2 shRNA Plasmid (h)

sc-72012-SHhGene SilencingPuromycin0
(0)

RyR-2 shRNA (h) Lentiviral Particles

sc-72012-VhGene SilencingPuromycin0
(0)

RyR-2 siRNA (m)

sc-153186mGene SilencingN/A0
(0)

RyR-2 shRNA Plasmid (m)

sc-153186-SHmGene SilencingPuromycin0
(0)

RyR-2 shRNA (m) Lentiviral Particles

sc-153186-VmGene SilencingPuromycin0
(0)

RyR-3 siRNA (h)

sc-42638hGene SilencingN/A0
(0)

RyR-3 shRNA Plasmid (h)

sc-42638-SHhGene SilencingPuromycin0
(0)

RyR-3 shRNA (h) Lentiviral Particles

sc-42638-VhGene SilencingPuromycin0
(0)

RyR-3 siRNA (m)

sc-42639mGene SilencingN/A0
(0)

RyR-3 shRNA Plasmid (m)

sc-42639-SHmGene SilencingPuromycin0
(0)

RyR-3 shRNA (m) Lentiviral Particles

sc-42639-VmGene SilencingPuromycin0
(0)

RyR-3 siRNA (r)

sc-61884rGene SilencingN/A0
(0)

RyR-3 shRNA Plasmid (r)

sc-61884-SHrGene SilencingPuromycin0
(0)

RyR-3 shRNA (r) Lentiviral Particles

sc-61884-VrGene SilencingPuromycin0
(0)