RyR-1 Antibody (8.U.100): sc-71989
- RyR-1 Antibody (8.U.100) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- raised against skeletal muscle triads of rabbit origin
- recommended for detection of skeletal muscle ryanodine receptor Ca2+ channel of mouse, rat, rabbit and canine origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for RyR-1 Antibody (8.U.100). This work is in progress.
QUICK LINKS
RyR-1 Antibody (8.U.100) is a mouse monoclonal IgM antibody that detects RyR-1 in mouse, rat, rabbit, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. RyR-1, a member of the ryanodine receptor family, plays a crucial role in calcium signaling within muscle cells, specifically in the excitation-contraction coupling process. Located primarily in the sarcoplasmic reticulum of skeletal muscle, RyR-1 is responsible for the release of calcium ions in response to membrane depolarization, which is essential for muscle contraction. The proper functioning of RyR-1 is vital, as any mutations in its gene can lead to severe muscle disorders such as Brody disease, malignant hyperthermia, cardiomyopathy, and central core disease. Anti-RyR-1 antibody (8.U.100) enables researchers to effectively study the expression and regulation of RyR-1, contributing to a better understanding of muscle physiology and the pathophysiology of related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RyR-1 Antibody (8.U.100) References:
- The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor. | Grabner, M., et al. 1999. J Biol Chem. 274: 21913-9. PMID: 10419512
- Buthus martensi Karsch agonist of skeletal-muscle RyR-1, a scorpion active polypeptide: antinociceptive effect on rat peripheral nervous system and spinal cord, and inhibition of voltage-gated Na(+) currents in dorsal root ganglion neurons. | Tan, ZY., et al. 2001. Neurosci Lett. 297: 65-8. PMID: 11121871
- Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression. | Avila, G., et al. 2001. J Biol Chem. 276: 17732-8. PMID: 11278546
- Functional importance and caffeine sensitivity of ryanodine receptors in primary lymphocytes. | Ritter, M., et al. 2001. Int Immunopharmacol. 1: 339-47. PMID: 11360934
- Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers. | Matsusue, A., et al. 2011. Leg Med (Tokyo). 13: 7-11. PMID: 20952238
- IL-1α reversibly inhibits skeletal muscle ryanodine receptor. a novel mechanism for critical illness myopathy? | Friedrich, O., et al. 2014. Am J Respir Cell Mol Biol. 50: 1096-106. PMID: 24400695
- Omecamtiv mecarbil activates ryanodine receptors from canine cardiac but not skeletal muscle. | Nánási, P., et al. 2017. Eur J Pharmacol. 809: 73-79. PMID: 28506910
- Human genome--chromosome no. 19. | Sokol, L. and Prchal, JT. 1995. Cas Lek Cesk. 134: 625-9. PMID: 7585875
- Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor. | Takeshima, H., et al. 1995. EMBO J. 14: 2999-3006. PMID: 7621815
- A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle. | Yamazawa, T., et al. 1997. J Biol Chem. 272: 8161-4. PMID: 9079632
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RyR-1 Antibody (8.U.100) | sc-71989 | 200 µg/ml | $322.00 |