RyR-1 Antibody (XA7B6): sc-73607

RyR-1 Antibody (XA7B6) is a mouse monoclonal IgM antibody that detects RyR-1 in mouse, rat, rabbit, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. RyR-1, a member of the ryanodine receptor family, plays a crucial role in calcium signaling within muscle cells, specifically in the excitation-contraction coupling process. Located primarily in the sarcoplasmic reticulum of skeletal muscle, RyR-1 is responsible for the release of calcium ions in response to membrane depolarization, which is essential for muscle contraction. The proper functioning of RyR-1 is vital, as any mutations in its gene can lead to severe muscle disorders such as Brody disease, malignant hyperthermia, cardiomyopathy, and central core disease, highlighting its importance in maintaining muscle health and function. RyR-1 (XA7B6) antibody is an invaluable tool for researchers studying these critical pathways and the associated pathologies, providing insights into the molecular mechanisms underlying muscle contraction and related diseases.

The preferred RyR antibody is RyR Antibody (F-1): sc-376507.