RUNDC3B Inhibitors
Chemical inhibitors of RUNDC3B function through diverse mechanisms to disrupt the signaling pathways that RUNDC3B is involved in. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit the activity of kinases that phosphorylate RUNDC3B or its associated proteins, leading to a functional inhibition of its role in signal transduction. GW5074, as a c-Raf kinase inhibitor, can disrupt the Raf kinase-mediated pathways essential for RUNDC3B's activity. Similarly, LY294002 and Wortmannin, both PI3K inhibitors, can block the PI3K/Akt pathway, which is crucial for many cellular processes that RUNDC3B may regulate. PD98059 and U0126, which are inhibitors of MEK1/2, prevent the activation of the MEK/ERK pathway, potentially inhibiting RUNDC3B's function if it relies on this signaling cascade.
Further, SP600125, as a JNK inhibitor, can prevent the phosphorylation events necessary for RUNDC3B-involved signal transduction. SB203580 can inhibit the p38 MAP kinase pathway, disrupting the signaling cascade and thus RUNDC3B's role within it. PP2, an Src kinase inhibitor, can inhibit Src kinase signaling, which may be pivotal for RUNDC3B's function. Rapamycin, an mTOR pathway inhibitor, can interrupt a pathway involving cell growth and proliferation that RUNDC3B may be a part of. Y-27632, a ROCK inhibitor, can hinder the Rho/ROCK pathway signaling, thereby inhibiting RUNDC3B if it interacts with this pathway. Lastly, ZM-447439, an Aurora kinase inhibitor, can disrupt cell cycle or spindle assembly processes that RUNDC3B may regulate, thus inhibiting its functional activity. Each of these inhibitors targets specific molecular signaling pathways, thereby modulating the functional activity of RUNDC3B by inhibiting the enzymes and kinases that activate or modulate it.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Given that RUNDC3B has been reported to interact with proteins that are involved in various signaling pathways, staurosporine can inhibit RUNDC3B by inhibiting the kinases that phosphorylate and activate RUNDC3B or its partner proteins, leading to a functional inhibition of RUNDC3B's role in signal transduction. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is a c-Raf kinase inhibitor. RUNDC3B, being associated with signaling pathways, might rely on Raf kinase-mediated pathways for its function. Inhibition of c-Raf by GW5074 could therefore disrupt the downstream signaling required for RUNDC3B's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that would inhibit the PI3K/Akt pathway. RUNDC3B, if interacting with the PI3K/Akt pathway, would be functionally inhibited due to the disruption of this signaling cascade that is essential for many cellular processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that blocks the MEK/ERK pathway. RUNDC3B's functional activity could be dependent on the MEK/ERK pathway signaling, and inhibition of this pathway by PD98059 would result in functional inhibition of RUNDC3B. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK. Inhibition of JNK could lead to functional inhibition of RUNDC3B if RUNDC3B is involved in JNK-related signaling pathways, as it would prevent the phosphorylation events necessary for signal transduction involving RUNDC3B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. Since RUNDC3B might be involved in p38 MAPK pathway-related signaling, inhibition of this kinase would disrupt the signaling cascade, thus inhibiting RUNDC3B's functional role within this pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, which blocks the PI3K/Akt pathway. By inhibiting PI3K, the downstream Akt pathway is interrupted, potentially leading to a functional inhibition of RUNDC3B if RUNDC3B is involved in this pathway. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src kinase inhibitor. Src kinase signaling is pivotal in various cellular processes, and if RUNDC3B's function is related to Src kinase signaling, then PP2 would inhibit this pathway, leading to inhibition of RUNDC3B. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. Inhibition of MEK1/2 would prevent the activation of ERK and potentially inhibit RUNDC3B's functional role if it is ERK-dependent. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and proliferation. Inhibition of mTOR could functionally inhibit RUNDC3B if RUNDC3B's function is associated with mTOR pathway signaling. | ||||||