RTCD1 Inhibitors
Chemical inhibitors of RTCD1 include a range of compounds that act on different signaling pathways and kinases, which are crucial for the protein's function. Staurosporine, a broad-spectrum kinase inhibitor, can inhibit the phosphorylation of RTCD1, assuming RTCD1's activity is regulated by phosphorylation. Bisindolylmaleimide I specifically targets protein kinase C, which, if involved in phosphorylating RTCD1, would prevent this modification process, leading to a decrease in RTCD1 activity. The PI3K inhibitors LY294002 and Wortmannin can obstruct the PI3K pathway, which might be essential for the downstream signaling that activates RTCD1, thereby suppressing RTCD1's function. Similarly, PD98059 and U0126, as MEK inhibitors, can diminish the activity of the ERK/MAPK pathway, potentially reducing the activation or effectiveness of RTCD1.
Furthermore, SP600125, by inhibiting JNK, can prevent the initiation of signaling pathways necessary for RTCD1's activity. In parallel, SB203580 can inhibit p38 MAP kinase, potentially blocking another pathway that may contribute to RTCD1's function. Sorafenib, by inhibiting Raf kinase, can interfere with the Raf/MEK/ERK signaling pathway, which might be necessary for the proper functioning of RTCD1. Rapamycin, through mTOR inhibition, can disrupt cellular processes on which RTCD1 depends, leading to its inhibition. Finally, EGFR inhibitors such as Gefitinib and Erlotinib can prevent the activation of downstream signaling cascades that RTCD1 relies on, ensuring that RTCD1's activity is suppressed.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
As a kinase inhibitor, staurosporine can inhibit the phosphorylation of RTCD1 if RTCD1 is regulated by phosphorylation through any kinase susceptible to staurosporine, leading to functional inhibition of RTCD1. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Targets protein kinase C which may phosphorylate RTCD1; inhibition of this kinase would prevent the phosphorylation and subsequent activation of RTCD1, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, potentially preventing the activation of downstream signaling proteins that RTCD1 requires for its full activity, leading to the functional inhibition of RTCD1. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Acts as a PI3K inhibitor which could prevent the activation of downstream signaling proteins involved in RTCD1's function, leading to its functional inhibition. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
As a MEK inhibitor, PD98059 would inhibit the ERK/MAPK pathway, which could be upstream of RTCD1 activation, thereby reducing the phosphorylation levels and subsequent activity of RTCD1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK, potentially leading to reduced ERK/MAPK pathway activity, which could be required for RTCD1 activation or function, resulting in RTCD1 inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
JNK inhibitor, which by inhibiting JNK could prevent the activation of signaling pathways that are necessary for RTCD1's function, leading to its inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAP kinase which could be involved in signaling pathways necessary for RTCD1's activity, leading to its functional inhibition. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
As a Raf kinase inhibitor, Sorafenib could disrupt the Raf/MEK/ERK signaling pathway, potentially impairing processes that activate or stabilize RTCD1, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, which may disrupt cellular processes vital to RTCD1 function, leading to the inhibition of RTCD1 activity. | ||||||