Rosbin Inhibitors
Chemical inhibitors of Rosbin can function through various molecular mechanisms to inhibit its activity. Trichostatin A and Bortezomib, for instance, act through the modification of protein acetylation and degradation processes, respectively. Trichostatin A inhibits histone deacetylases, leading to increased acetylation of histones and other proteins, which can alter gene expression and inhibit the signaling pathways that Rosbin is a part of. In contrast, Bortezomib disrupts the ubiquitin-proteasome system, which could prevent the degradation of proteins that negatively regulate Rosbin, thereby inhibiting its function. Furthermore, kinase inhibitors such as LY294002, Wortmannin, PD98059, U0126, SP600125, Dasatinib, and Imatinib target various kinases that Rosbin may rely on for its signaling functions. LY294002 and Wortmannin specifically inhibit phosphatidylinositol 3-kinase, while PD98059 and U0126 target MEK in the MAPK/ERK pathway, SP600125 inhibits c-Jun N-terminal kinase, and Dasatinib and Imatinib inhibit Src kinase and other tyrosine kinases, respectively.
Other chemical inhibitors focus on different aspects of cellular regulation. For example, Rapamycin binds to FKBP12 to inhibit the mTOR pathway, which is crucial for cell growth and metabolism, and if Rosbin is related to this pathway, its inhibition can occur. SB203580 targets the p38 MAP kinase within the MAPK pathway, which is involved in the cellular response to stress and cytokines, indicating that if Rosbin's activity is related to stress responses, SB203580 can be an effective inhibitor. ZM-447439, an Aurora kinase inhibitor, affects cell cycle control, suggesting that if Rosbin is involved in cell cycle regulation, ZM-447439 would inhibit its function by targeting this pathway. Together, these chemical inhibitors can influence the regulatory network and signaling pathways essential for Rosbin's activity, leading to its inhibition through a range of distinct molecular mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can enhance the acetylation of histones, leading to changes in chromatin structure and affecting gene expression. By altering the expression of certain genes, Trichostatin A can inhibit the signaling pathways in which Rosbin is involved, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K), which is involved in various signaling pathways, including those regulating cell growth and survival. Inhibition of PI3K by LY294002 could decrease the activation of downstream targets that may be critical for Rosbin function, thereby inhibiting Rosbin's activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 can prevent the activation of extracellular signal-regulated kinase (ERK), potentially reducing the activity of Rosbin if it relies on this pathway for its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase, part of the MAPK pathway, which is involved in cellular responses to stress and cytokines. If Rosbin's activity is regulated by the p38 MAPK pathway, inhibition by SB203580 will result in decreased Rosbin function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a steroidal metabolite that acts as a potent inhibitor of PI3K. Similar to LY294002, Wortmannin's inhibition of PI3K can blunt downstream signaling pathways that are potentially necessary for Rosbin activity, resulting in its functional inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that binds to the FKBP12 and blocks the activity of mTORC1, which is central to cellular growth and metabolism. The inhibition of mTORC1 by Rapamycin could suppress pathways critical for the function of Rosbin, leading to its inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), which modulates transcription factors and other proteins. Inhibiting JNK could lead to the suppression of cellular processes in which Rosbin is functionally involved, thereby inhibiting its action. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of ERK1/2. If Rosbin requires ERK1/2 activation for its function, U0126's inhibition of MEK would result in Rosbin inhibition. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Aurora kinases play a role in the regulation of mitosis. If Rosbin is involved in cell cycle control and requires Aurora kinase activity, ZM-447439 would inhibit its function by targeting this specific pathway. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src kinase inhibitor that also inhibits other tyrosine kinases. By inhibiting Src kinase activity, Dasatinib could disrupt signaling pathways that are essential for Rosbin activity, resulting in its functional inhibition. | ||||||