RNF168 Inhibitors
RNF168 inhibitors represent a diverse array of chemicals that modulate the cellular functions of RNF168 by targeting specific signaling pathways. Nutlin-3, although not a direct inhibitor, can indirectly suppress RNF168 by stabilizing p53 and subsequently reducing RNF168 transcription. Wortmannin and LY294002, both PI3K inhibitors, disrupt PI3K-AKT signaling pathways intertwined with RNF168-regulated DNA damage responses. KU-55933 and ATM Kinase Inhibitor II target ATM kinase, hindering RNF168 phosphorylation and its subsequent involvement in DNA repair. Mirin, an MRN complex inhibitor, indirectly affects RNF168 by disrupting its interaction with the MRN complex during DNA damage response.
NSC 19630 and NU7026, DNA-PK inhibitors, influence RNF168 by disrupting the DNA-PK-mediated DNA repair pathways in which RNF168 participates. Ku-0060648 and VE-821, inhibitors of ATR kinase, indirectly inhibit RNF168 by disrupting ATR-mediated signaling involved in DNA damage responses. CGK 733 and AZD7762, inhibitors of checkpoint kinases Chk2 and Chk1, respectively, modulate RNF168 phosphorylation and its functional involvement in checkpoint activation. Collectively, these RNF168 inhibitors offer insights into the intricate molecular mechanisms through which diverse chemicals can modulate RNF168, providing valuable tools for dissecting RNF168-associated pathways in DNA damage responses and checkpoint regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(–)-Nutlin-3 | 675576-98-4 | sc-222086 sc-222086A | 1 mg 5 mg | $122.00 $219.00 | 2 | |
Nutlin-3 is a small molecule inhibitor of the p53-MDM2 interaction. While not directly targeting RNF168, Nutlin-3 can indirectly inhibit RNF168 by preventing p53 degradation. p53 is a negative regulator of RNF168 transcription, and its stabilization can lead to decreased RNF168 expression, impacting its cellular functions in DNA damage response pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. RNF168 is involved in DNA damage response pathways that intersect with PI3K signaling. Wortmannin, by inhibiting PI3K, can potentially disrupt these pathways, indirectly inhibiting RNF168 and impairing its functions in DNA repair and checkpoint activation. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
KU-55933 is an ATM kinase inhibitor. RNF168 is known to be regulated by ATM-mediated phosphorylation. Inhibition of ATM by KU-55933 can potentially disrupt the phosphorylation events on RNF168, leading to its functional inhibition and impairment of its role in DNA damage response pathways. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $141.00 | 4 | |
Mirin is an inhibitor of MRN complex, which is involved in DNA damage repair. RNF168 interacts with the MRN complex during the DNA damage response. Mirin, by inhibiting the MRN complex, can indirectly affect RNF168 function, disrupting its participation in DNA repair and checkpoint signaling pathways. | ||||||
MIRA-1 | 72835-26-8 | sc-204087 sc-204087A | 10 mg 50 mg | $118.00 $452.00 | 1 | |
MIRA-1 (NSC 19630) is a DNA-dependent protein kinase (DNA-PK) inhibitor. RNF168 is implicated in the non-homologous end-joining (NHEJ) pathway, where DNA-PK plays a crucial role. Inhibition of DNA-PK by NSC 19630 can potentially disrupt NHEJ-mediated DNA repair, indirectly inhibiting RNF168 and affecting its functions in DNA damage response pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor, similar to Wortmannin. By inhibiting PI3K, LY294002 can influence the PI3K-AKT signaling pathway, which intersects with DNA damage response pathways involving RNF168. The indirect inhibition of RNF168 by LY294002 may occur through disruption of these interconnected signaling cascades, affecting RNF168's cellular functions. | ||||||
DNA-PK Inhibitor II | 154447-35-5 | sc-202143 sc-202143A | 10 mg 50 mg | $155.00 $660.00 | 6 | |
DNA-PK Inhibitor II (NU7026) is a DNA-dependent protein kinase (DNA-PK) inhibitor. RNF168 participates in the DNA damage response pathways involving DNA-PK. Inhibition of DNA-PK by NU7026 can indirectly inhibit RNF168, disrupting its role in DNA repair processes and checkpoint activation. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
CGK 733 is a checkpoint kinase 2 (Chk2) inhibitor. RNF168 is known to be regulated by Chk2-mediated phosphorylation. Inhibition of Chk2 by CGK 733 can potentially disrupt the phosphorylation events on RNF168, leading to its functional inhibition and impairment of its role in DNA damage response pathways. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 is a selective Chk1 inhibitor. RNF168 is linked to Chk1-mediated DNA damage response pathways. Inhibition of Chk1 by AZD7762 can potentially disrupt the downstream events regulated by Chk1, indirectly inhibiting RNF168 and impacting its functions in DNA repair and checkpoint activation. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is an inhibitor of ATR kinase, similar to Ku-0060648. Inhibition of ATR by VE-821 can potentially disrupt the downstream events regulated by ATR, indirectly inhibiting RNF168 and impacting its functions in DNA repair and checkpoint activation. | ||||||