RNF168 Antibody (B-11): sc-101125

RNF168 (B-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects RNF168 protein of mouse, rat and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA). RNF168 (B-11) antibody is available as the non-conjugated anti-RNF168 antibody. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF168 (RING finger protein 168) is a 571 amino acid protein that contains one RING-type zinc finger. Via its RING-type zinc finger, RNF168 may play a role in transcriptional regulation and protein degradation events. The gene encoding RNF168 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

RNF168 Antibody (B-11) References:

1. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.  |  Lorick, KL., et al. 1999. Proc Natl Acad Sci U S A. 96: 11364-9. PMID: 10500182
2. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.  |  Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
3. [New tumor suppressor genes in hot spots of human chromosome 3: new methods of identification].  |  Braga, EA., et al. 2003. Mol Biol (Mosk). 37: 194-211. PMID: 12723467
4. Plasticity of human chromosome 3 during primate evolution.  |  Tsend-Ayush, E., et al. 2004. Genomics. 83: 193-202. PMID: 14706448
5. Functional proteomics mapping of a human signaling pathway.  |  Colland, F., et al. 2004. Genome Res. 14: 1324-32. PMID: 15231748
6. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'.  |  Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
7. Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.  |  Penengo, L., et al. 2006. Cell. 124: 1183-95. PMID: 16499958
8. RNF168 facilitates proliferation and invasion of esophageal carcinoma, possibly via stabilizing STAT1.  |  Yu, N., et al. 2019. J Cell Mol Med. 23: 1553-1561. PMID: 30506884
9. RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.  |  Patel, PS., et al. 2021. J Clin Invest. 131: PMID: 33529165
10. UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.  |  Lee, SO., et al. 2023. J Biol Chem. 299: 105043. PMID: 37451480
11. Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair.  |  Feng, LL., et al. 2024. Proc Natl Acad Sci U S A. 121: e2322972121. PMID: 38968116
12. The RING finger domain: a recent example of a sequence-structure family.  |  Borden, KL. and Freemont, PS. 1996. Curr Opin Struct Biol. 6: 395-401. PMID: 8804826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RNF168 Antibody (B-11) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-RNF168 Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RNF168 Antibody (B-11) Specifications

Alternate Product Name: RNF168

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 462-572

Epitope Target: RNF168

Epitope Species: human

Product Reactivity/Detection: RNF168

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for RNF168 Antibody (B-11): N/A