RNF113A Inhibitors
RNF113A inhibitors comprise a group of chemical compounds that target various aspects of the ubiquitin-proteasome system, which is central to the protein's function. The inhibition of RNF113A is often achieved indirectly through the manipulation of this system. For instance, specific inhibitors target the proteasome itself, leading to the accumulation of ubiquitinated proteins. This accumulation can saturate the E3 ligase activity of RNF113A, thereby diminishing its ability to ubiquitinate additional substrates and effectively reducing its functional capacity. Other inhibitors work by interfering with the neddylation process that is vital for the functioning of other ubiquitin ligases, potentially affecting the activity of RNF113A due to the complex interplay and balance within the ubiquitin ligase family.
Furthermore, some compounds inhibit the ubiquitin-activating enzyme E1, resulting in a decreased ubiquitin conjugation, which is a prerequisite for RNF113A to exert its E3 ligase activity. By reducing the available ubiquitin pool, these inhibitors indirectly suppress the function of RNF113A. Additionally, the blockade of deubiquitinating enzymes through certain inhibitors leads to an enhanced degradation of RNF113A's substrates. This heightened degradation can alter the equilibrium of the ubiquitin-proteasome pathway, where RNF113A plays a role, and as a consequence, inhibits the protein's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins, leading to the accumulation of RNF113A's substrates and thereby reducing RNF113A's functional activity due to substrate overload. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
An irreversible proteasome inhibitor that leads to the accumulation of polyubiquitinated proteins, potentially saturating RNF113A's E3 ligase activity and indirectly inhibiting its function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A dipeptidyl boronic acid analog that inhibits the 26S proteasome, causing an increase in ubiquitinated proteins and indirectly reducing RNF113A activity by inhibiting substrate degradation. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
An epoxyketone-based proteasome inhibitor that impairs the degradation of ubiquitin-conjugated proteins, thus inhibiting RNF113A activity by disrupting its substrate turnover. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
An inhibitor of NEDD8-activating enzyme, preventing neddylation of cullin proteins and affecting the function of cullin-RING ligases (CRLs), which could indirectly impact RNF113A activity due to the interplay between different ubiquitin ligases. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An inhibitor of ubiquitin-activating enzyme E1, leading to decreased ubiquitin conjugation and indirectly inhibiting RNF113A's E3 ligase activity by reducing the available ubiquitin pool. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
A USP14 inhibitor that prevents deubiquitination of proteasome-bound proteins, potentially leading to reduced RNF113A activity due to enhanced degradation of RNF113A substrates. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $75.00 $184.00 $423.00 | 1 | |
A broad-spectrum deubiquitinase inhibitor that could lead to the accumulation of ubiquitinated proteins and indirectly inhibit RNF113A by overwhelming its E3 ligase capacity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that leads to the build-up of polyubiquitinated proteins, thereby indirectly inhibiting RNF113A's ubiquitination process due to substrate accumulation. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $68.00 $210.00 $780.00 $1880.00 | 19 | |
An alkylating agent that inactivates cysteine proteases and could inhibit deubiquitinating enzymes, indirectly affecting RNF113A's function by disrupting the ubiquitin-proteasome pathway. | ||||||