RmlB Activators
RmlB Activators can be understood as chemicals that indirectly influence the activity of RmlB, also known as tRNA-guanine transglycosylase (TGDS), a protein involved in the biosynthesis of queuosine, a modified nucleoside present in tRNA. These compounds generally function by modulating various aspects of tRNA biosynthesis, thereby influencing TGDS's role. For instance, dTTP, dCTP, dATP, and dGTP can increase the available nucleotide pool for tRNA biosynthesis, potentially influencing TGDS activity. Guanosine, serving as a substrate for TGDS, can indirectly affect its function. Similarly, adenosine, cytidine, and thymidine can impact the nucleoside pool available for tRNA biosynthesis, thereby potentially influencing TGDS activity.
In addition, arabinosylcytosine, azidothymidine, ribavirin, and tenofovir, all being nucleoside analogs, can affect tRNA biosynthesis and potentially influence TGDS activity. For example, arabinosylcytosine and azidothymidine, being cytosine and thymidine analogs respectively, can influence the incorporation of these nucleotides into tRNA, potentially modulating TGDS's role in queuosine biosynthesis. Similarly, ribavirin and tenofovir, as guanosine and adenosine analogs, can affect the incorporation of these nucleotides into tRNA and potentially manipulate the activity of TGDS.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanosine | 118-00-3 | sc-218575 sc-218575A sc-218575B sc-218575C sc-218575D | 5 g 25 g 250 g 1 kg 5 kg | $40.00 $50.00 $84.00 $250.00 $1103.00 | ||
Guanosine serves as a substrate for TGDS in the biosynthesis of queuosine and can indirectly affect TGDS activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine can indirectly affect TGDS by impacting the pool of nucleosides available for tRNA biosynthesis. | ||||||
Thymidine | 50-89-5 | sc-296542 sc-296542A sc-296542C sc-296542D sc-296542E sc-296542B | 1 g 5 g 100 g 250 g 1 kg 25 g | $49.00 $73.00 $270.00 $458.00 $1758.00 $114.00 | 16 | |
Thymidine can indirectly affect TGDS by altering the pool of nucleosides available for tRNA biosynthesis. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
Arabinosylcytosine, a cytosine analog, can influence tRNA biosynthesis, potentially affecting TGDS activity. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $61.00 | 2 | |
Azidothymidine, a thymidine analog, can influence tRNA biosynthesis, potentially affecting TGDS activity. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin, a guanosine analog, can influence tRNA biosynthesis, potentially affecting TGDS activity. | ||||||
Tenofovir | 147127-20-6 | sc-204335 sc-204335A | 10 mg 50 mg | $157.00 $646.00 | 11 | |
Tenofovir, an adenosine analog, can influence tRNA biosynthesis, potentially affecting TGDS activity. | ||||||