RLTPR Activators
RLTPR Activators are chemicals that can indirectly modulate the activity of RLTPR by affecting the pathways it is involved in. RLTPR, or RGD, leucine-rich repeat, tropomodulin and proline-rich containing protein, is a cytosolic protein that has been identified as a crucial regulator in immune cell signaling, particularly in T-cells. It is known to play a role in the costimulation of T-cell receptors (TCR) which is essential for T-cell activation and function.
Direct RLTPR activators could bind to specific domains of the protein, inducing conformational changes that may lead to an increased affinity for its interacting partners or substrates. This could potentially enhance the protein's role in T-cell signaling pathways, possibly by facilitating the assembly of signaling complexes at the site of TCR activation. Indirect RLTPR activators might work by influencing the transcriptional or translational mechanisms that control RLTPR expression, leading to a higher concentration of the protein in the cell. They might also interfere with the degradation pathways responsible for RLTPR turnover, thereby prolonging its cellular lifespan. Post-translational modifications such as phosphorylation, ubiquitination, or sumoylation can alter the activity, localization, or stability of proteins, and thus, compounds that modify such processes could also serve as indirect activators of RLTPR.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of Protein Kinase C (PKC), which is involved in TCR signaling. By activating PKC, PMA might indirectly modulate RLTPR activity by impacting TCR signaling. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that can stimulate the calcineurin pathway, which is involved in TCR signaling. By affecting this pathway, Ionomycin can indirectly modulate RLTPR. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A is an inhibitor of calcineurin. By modulating the calcineurin pathway, it can indirectly affect RLTPR activity. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506 is another inhibitor of calcineurin. It can indirectly modulate RLTPR through its effect on the calcineurin pathway. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin B is an actin depolymerization agent. As RLTPR is associated with actin cytoskeleton remodeling, Latrunculin B can indirectly influence RLTPR. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide is an actin polymerization agent. It can indirectly modulate RLTPR by affecting actin cytoskeleton dynamics. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D is another actin depolymerization agent. It can indirectly influence RLTPR by modulating actin cytoskeleton remodeling. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule depolymerization agent. As microtubules are related to cytoskeleton dynamics, Nocodazole can indirectly modulate RLTPR. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel is a microtubule-stabilizing agent. It can indirectly influence RLTPR by affecting microtubule dynamics. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine is another microtubule depolymerization agent. It can indirectly modulate RLTPR by affecting microtubule dynamics. | ||||||