RIP15 Inhibitors
RIP15 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of RIP15, a protein thought to be involved in signaling pathways that regulate cellular processes such as apoptosis, inflammation, or immune response. RIP15 belongs to the Receptor-Interacting Protein (RIP) kinase family, a group of proteins known for their roles in mediating interactions between cell surface receptors and intracellular signaling pathways. These kinases typically function by phosphorylating target proteins, triggering downstream signaling cascades that influence cell survival, immune regulation, or stress responses. Inhibition of RIP15 can interfere with its kinase activity, preventing the phosphorylation of its targets and altering the cellular pathways it regulates.
The development of RIP15 inhibitors involves a deep understanding of the protein's structure, particularly its kinase domain, which is responsible for its enzymatic activity. Inhibitors are usually designed to bind to the active site of the kinase, blocking its ability to transfer phosphate groups to target proteins. Structural biology techniques such as X-ray crystallography and molecular docking are commonly used to identify the binding sites within RIP15 and to guide the design of small molecules that can selectively inhibit its activity. Achieving specificity is crucial, as RIP15 shares conserved domains with other members of the RIP kinase family, and off-target effects could disrupt related proteins. RIP15 inhibitors are important tools for studying the specific signaling pathways mediated by this kinase, providing insights into how it regulates critical cellular processes such as apoptosis and immune signaling, as well as its broader role in maintaining cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW3965 | 405911-09-3 | sc-490151 sc-490151A sc-490151B | 10 mg 50 mg 1 g | $260.00 $872.00 $1637.00 | ||
GW3965 may trigger a negative feedback loop that reduces RIP15 expression through sustained agonist activity, leading to a compensatory decrease in receptor levels. | ||||||
GSK-2033 | 1221277-90-2 | sc-507544 | 5 mg | $210.00 | ||
GSK2033 may bind competitively to RIP15, thereby preventing activation by endogenous ligands and contributing to a decrease in the receptor's expression within the nucleus. | ||||||
22(S)-Hydroxycholesterol | 22348-64-7 | sc-214088 sc-214088A | 5 mg 10 mg | $184.00 $331.00 | 2 | |
Administration of 22(S)-Hydroxycholesterol could lead to the saturation of RIP15, which might initiate a homeostatic response to inhibit further expression of the receptor to maintain cholesterol balance. | ||||||
T 0901317 | 293754-55-9 | sc-202824 sc-202824A | 10 mg 50 mg | $87.00 $220.00 | 5 | |
While initially activating RIP15, long-term exposure to T 0901317 could initiate a homeostatic reduction in RIP15 expression to prevent excessive activation. | ||||||
CHOLESTYRAMINE RESIN | 11041-12-6 | sc-507509 | 5 g | $210.00 | ||
Cholestyramine binds bile acids, which could lead to a depletion of RIP15 endogenous agonists, thus potentially decreasing the receptor's expression through reduced ligand availability. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
By inhibiting HMG-CoA reductase, simvastatin could reduce the biosynthesis of cholesterol, thereby potentially reducing the expression of RIP15 by decreasing ligand synthesis for receptor activation. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $252.00 $495.00 | 9 | |
Atorvastatin may lower lipid levels systemically, potentially leading to a reduced expression of RIP15 by limiting the availability of activating ligands derived from the cholesterol pathway. | ||||||
Guggulsterone | 95975-55-6 | sc-203990 sc-203990A | 10 mg 50 mg | $145.00 $615.00 | 1 | |
Guggulsterone may act as a direct antagonist to RIP15, which could result in the decrease of receptor expression by hindering the receptor's normal transcriptional activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Ketoconazole's inhibition of cytochrome P450 enzymes could indirectly decrease the synthesis of endogenous RIP15 ligands, leading to a subsequent downregulation of receptor expression. | ||||||
Fluoxetine | 54910-89-3 | sc-279166 | 500 mg | $312.00 | 9 | |
Fluoxetine might indirectly lead to the downregulation of RIP15 expression by altering lipid homeostasis, potentially through off-target effects that reduce the availability of ligands necessary for RIP15 activation. | ||||||