Molecular structure of GSK-2033, CAS Number: 1221277-90-2
GSK-2033 (CAS 1221277-90-2)
Alternate Names:
GSK 2033 GSK2033 CHEMBL1093266 2,4,6-trimethyl-N-[[4-(3-methylsulfonylphenyl)phenyl]methyl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]benzenesulfonamide
CAS Number:
1221277-90-2
Molecular Weight:
591.70
Molecular Formula:
C29H28F3NO5S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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GSK-2033 (CAS 1221277-90-2) References
- Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. | Griffett, K. and Burris, TP. 2016. Biochem Biophys Res Commun. 479: 424-428. PMID: 27680310
- Separating the Anti-Inflammatory and Diabetogenic Effects of Glucocorticoids Through LXRβ Antagonism. | Patel, R., et al. 2017. Endocrinology. 158: 1034-1047. PMID: 28324010
- The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models. | Helder, RWJ., et al. 2020. Biochim Biophys Acta Mol Cell Biol Lipids. 1865: 158546. PMID: 31678517
- Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis. | Wang, P., et al. 2021. Front Immunol. 12: 647070. PMID: 33679812
- T0901317, an Agonist of Liver X Receptors, Attenuates Neuronal Apoptosis in Early Brain Injury after Subarachnoid Hemorrhage in Rats via Liver X Receptors/Interferon Regulatory Factor/P53 Upregulated Modulator of Apoptosis/Dynamin-1-Like Protein Pathway. | Dai, J., et al. 2021. Oxid Med Cell Longev. 2021: 8849131. PMID: 34194609
- NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis. | Ghosh, S., et al. 2021. Hepatology. 74: 3284-3300. PMID: 34310734
- Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration. | Wang, Y., et al. 2023. Life Sci Alliance. 6: PMID: 37550000
- Activation of LXRα attenuates 2-Ethylhexyl diphenyl phosphate (EHDPP) induced placental dysfunction. | Zhang, Y., et al. 2023. Ecotoxicol Environ Saf. 266: 115605. PMID: 37864966
- Activation of LXRs alleviates neuropathic pain-induced cognitive dysfunction by modulation of microglia polarization and synaptic plasticity via PI3K/AKT pathway. | Han, S., et al. 2024. Inflamm Res. 73: 157-174. PMID: 38183431
- TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia. | Li, Z., et al. 2024. Clin Transl Med. 14: e1665. PMID: 38649789
Inhibitor of:
2410131K14Rik, ERRβ, LXRβ, NR5A2, ORP-8, and RIP15.Activator of:
Angptl3, and TBL1X.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-2033, 5 mg | sc-507544 | 5 mg | $210.00 |