RINT-1 Inhibitors
Chemical inhibitors of RINT-1 target various aspects of the cellular machinery involved in vesicle trafficking, each affecting the protein's function in unique ways. Monastrol directly inhibits the motor protein Eg5, which is crucial for maintaining the organization of the Golgi apparatus during mitosis. The inhibition of Eg5 by Monastrol leads to disruption in mitotic spindle formation, ultimately impairing RINT-1's role in vesicle transport during cell division. Similarly, Nocodazole's binding to tubulin and inhibition of its polymerization disrupts microtubule dynamics, which are essential for RINT-1's associated vesicle transport. The resulting microtubule dysfunction inhibits RINT-1's ability to mediate this trafficking effectively. Paclitaxel, on the other hand, hyper-stabilizes microtubules, preventing their dynamic rearrangement which is necessary for RINT-1's role in vesicle trafficking.
Moreover, actin cytoskeleton disruptors like Cytochalasin D and Latrunculin A inhibit actin polymerization, thereby impairing RINT-1-mediated vesicular movement and fusion, as the actin cytoskeleton is integral to RINT-1's function. Brefeldin A inhibits ADP-ribosylation factor, a small GTPase involved in vesicle formation from the Golgi, disrupting the vesicular transport from the ER to the Golgi and thus inhibiting the function of RINT-1 in this process. Golgicide A targets GBF1, a guanine nucleotide exchange factor for ARF, and its inhibition disrupts Golgi apparatus functionality, which is necessary for RINT-1's role in vesicle trafficking. Dynasore's inhibition of dynamin GTPase activity directly impedes endocytic vesicle formation, thereby indirectly inhibiting RINT-1's function in endocytosis. Pitstop 2 inhibits clathrin-mediated endocytosis, blocking the vesicle formation and trafficking on which RINT-1 relies. Continuing this theme, Endosidin2 disrupts the EXO70 subunit of the exocyst complex, which is involved in the targeting and fusion of vesicles to the plasma membrane, inhibiting RINT-1's role in vesicular transport to the membrane. ML141, a selective inhibitor of Cdc42 GTPase, disrupts actin cytoskeleton organization, essential for RINT-1's function in vesicular trafficking. Lastly, SecinH3 inhibits cytohesins, disrupting ARF GTPase activity, which in turn inhibits RINT-1's role in ER to Golgi transport and overall vesicular trafficking.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a cell-permeable small molecule inhibitor known to specifically inhibit the motor protein Eg5 (kinesin-5). RINT-1 is involved in trafficking between the ER and Golgi, and Eg5 is essential for maintaining the organization of the Golgi apparatus during mitosis. Inhibition of Eg5 by Monastrol would disrupt the mitotic spindle formation and thus could lead to an indirect inhibition of RINT-1's function in vesicle transport during cell division. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a synthetic compound that disrupts microtubule dynamics by binding to tubulin and inhibiting its polymerization. RINT-1 is associated with microtubule-dependent vesicle transport; thus, the disruption of microtubules by Nocodazole would inhibit RINT-1's ability to mediate vesicle trafficking effectively. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel is a chemotherapeutic agent that stabilizes microtubules and prevents their depolymerization. By hyper-stabilizing microtubules, Paclitaxel can inhibit the dynamic rearrangement of microtubules required for RINT-1's role in vesicle trafficking. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is known to inhibit actin polymerization. Since RINT-1 is involved in vesicular trafficking, which relies on the actin cytoskeleton, inhibition of actin polymerization by Cytochalasin D would impair RINT-1-mediated vesicular movement and fusion. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers, preventing their polymerization. This actin disruption would inhibit RINT-1 function because RINT-1 requires the actin cytoskeleton for the trafficking and sorting of vesicles. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a small GTPase involved in vesicle formation from the Golgi. By inhibiting ARF, Brefeldin A would disrupt vesicular transport from the ER to the Golgi and thereby inhibit RINT-1's role in this process. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A specifically inhibits the Golgi BFA resistance factor 1 (GBF1), a guanine nucleotide exchange factor for ARF. Inhibition of GBF1 by Golgicide A will disrupt the function of the Golgi apparatus, which is necessary for RINT-1's role in vesicle trafficking. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a non-competitive inhibitor of the GTPase activity of dynamin, which is required for vesicle scission during endocytosis. By inhibiting dynamin, Dynasore would directly inhibit endocytic vesicle formation, thus indirectly inhibiting RINT-1's function in this process. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is an inhibitor of clathrin-mediated endocytosis. It would inhibit RINT-1's function by blocking vesicle formation and trafficking, processes in which RINT-1 is involved. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of Cdc42 GTPase. By inhibiting Cdc42, ML141 would disrupt actin cytoskeleton organization, which is essential for RINT-1's function in vesicular trafficking. | ||||||