Ribosomal Protein L7A Activators
Ribosomal Protein L7A Activators are chemical compounds that enhance the functional activity of Ribosomal Protein L7A (RPL7A). RPL7A is a component of the large 60S subunit of the ribosome, directly participating in the protein synthesis process. These activators operate through various signaling pathways that can indirectly influence the function of RPL7A, either through its role in the ribosome or by modifying the cellular environment in which it operates.
Forskolin, 8-Bromo-cAMP, IBMX, and Rolipram function by enhancing levels of cyclic AMP in cells, leading to activation of Protein Kinase A (PKA). RPL7A activity can be enhanced by PKA activation since this kinase can phosphorylate and activate factors involved in ribosomal assembly and function. Similarly, Okadaic Acid, Calyculin A, and Cantharidin inhibit protein phosphatases 1 and 2A, maintaining the phosphorylation state of ribosomal proteins and other factors involved in ribosomal assembly and function, potentially enhancing RPL7A activity.
On the other hand,Staurosporine, Phorbol 12-myristate 13-acetate (PMA), and Bisindolylmaleimide I modulate protein kinase activity in the cellular milieu. Staurosporine's broad-spectrum inhibition of protein kinases and PMA's potent activation of Protein Kinase C (PKC) can affect the phosphorylation state of factors involved in ribosomal assembly and function, indirectly enhancing RPL7A activity. Bisindolylmaleimide I, as a potent and selective inhibitor of PKC, also contributes to the modulation of these phosphorylation states. Furthermore, U0126 and PD98059 act as inhibitors of MEK1/2, a kinase that sits upstream of ERK in the MAPK signaling pathway. By modulating this pathway, these chemicals can influence the phosphorylation state of factors involved in ribosomal assembly and function, indirectly leading to enhanced RPL7A activity. These Ribosomal Protein L7A Activators, despite their diverse mechanisms of action, collectively contribute to the enhancement of RPL7A's role in protein synthesis within the cell, offering an intricate network of control over this essential cellular process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, increasing levels of cyclic AMP. This can enhance Ribosomal Protein L7A activity by stimulating PKA, which can phosphorylate and activate factors involved in ribosomal assembly and function. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It may enhance Ribosomal Protein L7A activity by activating PKA, which can phosphorylate factors involved in ribosomal assembly and function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP and cGMP. By increasing cAMP levels, IBMX can enhance Ribosomal Protein L7A activity through PKA activation and subsequent phosphorylation of factors involved in ribosomal assembly and function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 inhibitor. It increases cAMP levels, leading to PKA activation, which can phosphorylate factors involved in ribosomal assembly and function, thereby enhancing Ribosomal Protein L7A activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A. By inhibiting these phosphatases, it maintains the phosphorylation state of ribosomal proteins and other factors involved in ribosomal assembly and function, potentially enhancing Ribosomal Protein L7A activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 and 2A. By maintaining the phosphorylation state of ribosomal proteins and other factors, it can enhance Ribosomal Protein L7A activity. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin is a potent and selective inhibitor of protein phosphatases 1 and 2A. By maintaining the phosphorylation state of ribosomal proteins and other factors, it can enhance Ribosomal Protein L7A activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It can indirectly enhance Ribosomal Protein L7A activity by modulating kinase activity and hence phosphorylation state of factors involved in ribosomal assembly and function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC can phosphorylate factors involved in ribosomal assembly and function, potentially enhancing Ribosomal Protein L7A activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a potent and selective inhibitor of PKC. By modulating PKC activity, it can influence the phosphorylation state of factors involved in ribosomal assembly and function, thereby enhancing Ribosomal Protein L7A activity. | ||||||