RIBC2 Inhibitors
TRIB proteins, short for "tribbles homolog," are a family of proteins that play a significant role in various cellular processes, including signaling pathways that regulate cell proliferation, differentiation, and metabolism. The name "tribbles" originates from a Drosophila melanogaster gene identified for its role in embryonic patterning. In humans, the TRIB family consists of three members: TRIB1, TRIB2, and TRIB3, each encoded by a corresponding gene TRIB1, TRIB2, and TRIB3, respectively.
TRIB proteins are characterized by a distinctive pseudokinase domain, which means they share structural similarity with kinases but generally lack enzymatic activity. Despite this, they interact with and modulate the activity of actual kinases and other signaling proteins, often acting as adaptors or scaffold proteins to regulate signal transduction pathways.TRIB1 has been implicated in lipid metabolism and is associated with conditions such as hyperlipidemia and coronary artery disease. It modulates pathways that involve key regulators of lipid metabolism, such as C/EBP alpha and signaling cascades involving MAPKs.TRIB2 is known to affect cell differentiation and has been linked to various cancers. It can influence the degradation of the transcription factor C/EBP alpha, thus affecting myeloid differentiation and contributing to the development of acute myeloid leukemia.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
This compound inhibits RNA polymerase II, potentially decreasing the transcription of genes like C22orf11. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
It intercalates into DNA, which could inhibit the transcription process and thus lower C22orf11 expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Known to suppress transcription broadly, this could lead to a general decrease in gene expression, including C22orf11. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
It can inhibit RNA polymerase II-dependent transcription elongation, possibly reducing C22orf11 mRNA levels. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
It inhibits cyclin-dependent kinases, which may affect transcription and potentially decrease C22orf11 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to GC-rich DNA sequences, it might block transcription factors and lower C22orf11 transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, it could alter methylation patterns and affect C22orf11 gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor might change chromatin structure and influence C22orf11 gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
It affects nucleic acid synthesis and could modify transcription, possibly impacting C22orf11 mRNA levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
By altering protein degradation, it may indirectly affect transcription factors and modulate C22orf11 expression. | ||||||