RIA1_Eftud1 Activators
RIA1_Eftud1 Activators are a diverse group of chemical compounds that indirectly facilitate the functional activity of the protein RIA1_Eftud1, which is implicated in ribosomal RNA processing and ribosome assembly. These activators do not engage directly with RIA1_Eftud1 but instead modulate various cellular signaling pathways and processes that can lead to the functional activation of RIA1_Eftud1. The mechanisms by which these chemicals act range from upregulation of cyclic AMP (cAMP) by forskolin and other phosphodiesterase inhibitors such as caffeine and IBMX, to alterations in transcriptional control from agents like dexamethasone and retinoic acid. Such modifications in signaling cascades and gene expression indirectly influence the ribosome biogenesis pathway, where RIA1_Eftud1 plays a crucial role.
The chemical class includes compounds that induce stress responses like sodium arsenite, which impacts protein folding and potentially enhances ribosome assembly processes involving RIA1_Eftud1. Additionally, AICAR's activation of AMPK suggests an energy-sensing adjustment, which could recalibrate mRNA transcription and processing relevant to RIA1_Eftud1's function. Rapamycin's inhibition of the mTOR pathway, which is central to protein synthesis, suggests a nuanced feedback regulation that may implicate RIA1_Eftud1. Furthermore, natural compounds such as curcumin and epigallocatechin gallate (EGCG) exert multiple cellular effects, including modulation of signal transduction and transcription factor activity, which could cascade down to the activity of RIA1_Eftud1. Lastly, chloroquine's RNA intercalation and Leptomycin B's inhibition of nuclear export alter the cellular distribution of ribosomal components, thereby indirectly influencing RIA1_Eftud1's role in ribosome assembly. Each of these activators, while diverse in structure and primary mode of action, converge on pathways that are likely to modulate the functional landscape in which RIA1_Eftud1 operates within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP acts as a second messenger, activating protein kinase A (PKA). PKA can phosphorylate various targets, including proteins that regulate RNA processing, potentially enhancing the maturation of ribosomal precursors which is part of the functional role of RIA1_Eftud1. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine acts as a phosphodiesterase inhibitor, preventing the breakdown of cAMP in cells, thereby increasing its concentration. The higher levels of cAMP can, in turn, activate PKA which may indirectly influence RNA processing and ribosome assembly functions associated with RIA1_Eftud1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is another phosphodiesterase inhibitor that increases intracellular cAMP by preventing its degradation. This increase in cAMP can activate PKA, which may indirectly affect RNA splicing and ribosome biogenesis, processes where RIA1_Eftud1 is potentially involved. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is known to have various cellular effects, including the modulation of signal transduction pathways. Its potential to alter transcription factors and RNA processing enzymes could indirectly impact RIA1_Eftud1 activity by affecting the maturation of ribosomal RNA and assembly of ribosomal subunits. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite induces oxidative stress and affects protein folding. Its impact on the cellular stress response can lead to the activation of pathways that enhance RNA processing and ribosome assembly, potentially influencing the activity of RIA1_Eftud1, which is involved in these cellular processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMP-activated protein kinase (AMPK), which is involved in cellular energy homeostasis. The activation of AMPK can potentially modulate various downstream pathways that influence mRNA transcription and processing, indirectly affecting the role of RIA1_Eftud1 in ribosome biogenesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which plays a critical role in the regulation of protein synthesis and ribosome biogenesis. Inhibition of this pathway might create a feedback mechanism that adjusts the processes in which RIA1_Eftud1 is involved, such as the maturation and export of the 60S ribosomal subunit. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone is a glucocorticoid that can act as a transcription factor modulator. It has the potential to regulate the expression of genes involved in RNA processing and ribosome biogenesis, thereby possibly influencing the activity of RIA1_Eftud1 indirectly through altered transcriptional programs. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, modulates gene expression and differentiation. It could indirectly affect the role of RIA1_Eftud1 in ribosome biogenesis by changing the expression of factors involved in RNA splicing and ribosome assembly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has multiple cellular targets and can modulate signal transduction pathways. By influencing transcription and possibly RNA processing, curcumin could indirectly affect RIA1_Eftud1 activity involved in ribosome assembly and RNA maturation. | ||||||