Retinal RX Activators
The chemical class Retinal RX Activators comprises a range of compounds primarily centered around retinoids and their synthetic analogs. These chemicals modulate the activity of Retinal RX proteins by either directly binding to these receptors or influencing their activation through related pathways. This modulation plays a significant role in various cellular processes, including cell differentiation, proliferation, apoptosis, and metabolism.
In the first category, natural compounds like retinoic acid and its derivatives, including 9-cis-β-Carotene and alitretinoin, bind directly to RXR, activating it and thereby influencing gene expression relevant to cell growth and differentiation. These compounds are crucial in the physiological processes controlled by RXR, including vision, immune function, and skin health. The second category includes synthetic retinoids like bexarotene, adapalene, tazarotene, and others. These compounds are designed to selectively activate RXR or related receptors like RAR. By binding to these receptors, they alter gene expression patterns, impacting cellular processes like lipid metabolism, skin cell differentiation, and apoptosis. Some of these compounds, such as LG100268 and LGD-1069, are specific agonists for RXR and play a significant role in modulating its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
A metabolite of Vitamin A, retinoic acid binds directly to RXR, influencing its activation and thereby modulating gene expression related to cell differentiation and growth. | ||||||
Bexarotene | 153559-49-0 | sc-217753 sc-217753A | 10 mg 100 mg | $55.00 $250.00 | 6 | |
A synthetic retinoid, bexarotene selectively activates RXR, leading to altered gene expression in processes like cell differentiation and apoptosis. | ||||||
LG 100268 | 153559-76-3 | sc-211737 | 5 mg | $390.00 | 2 | |
A RXR-specific agonist, it directly activates RXR, influencing genes involved in lipid metabolism and apoptosis. | ||||||
9-cis-β-Carotene | 13312-52-2 | sc-504699 | 10 mg | $6500.00 | ||
A precursor of 9-cis-retinoic acid, it can be metabolized into an active form that binds to RXR, modulating its activity. | ||||||
Adapalene | 106685-40-9 | sc-203803 sc-203803A | 10 mg 50 mg | $66.00 $332.00 | 2 | |
A synthetic analog of retinoic acid, adapalene binds to RXR and RAR (Retinoic Acid Receptor), influencing cellular processes like keratinization and inflammation. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
A prodrug converted to its active form, tazarotenic acid, which binds to RXR and RAR, affecting processes like cell proliferation and differentiation. | ||||||
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
A synthetic retinoid, Am80 selectively activates RAR, indirectly influencing RXR as part of the heterodimeric complex, affecting gene expression. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
A synthetic retinoid, 4-Hydroxyphenylretinamide binds to both RAR and RXR, influencing cell growth and apoptosis. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $151.00 | 1 | |
A second-generation retinoid, acitretin binds to RAR and RXR, modulating skin cell differentiation and proliferation. | ||||||
9-cis-Retinoic acid | 5300-03-8 | sc-205589 sc-205589B sc-205589C sc-205589D sc-205589A | 1 mg 25 mg 250 mg 500 mg 5 mg | $71.00 $424.00 $3121.00 $5722.00 $148.00 | 10 | |
The endogenous ligand for RXR, alitretinoin binds directly to RXR, influencing gene expression related to skin health and inflammation. | ||||||