REG3α Inhibitors
REG3α inhibitors represent a chemical class of compounds that specifically target and inhibit the activity of the protein Regenerating islet-derived protein 3 alpha (REG3α), a member of the C-type lectin family. REG3α is known for its role in binding carbohydrate structures, particularly peptidoglycan components, which makes it integral to interactions with bacterial cell walls. Structurally, REG3α contains a carbohydrate recognition domain (CRD) characteristic of C-type lectins, which facilitates its interaction with polysaccharides. Inhibitors of REG3α, therefore, are typically designed to disrupt this interaction, often by targeting the lectin-like domain or the critical residues involved in sugar binding. These inhibitors might also affect conformational changes in REG3α or interfere with its oligomerization, which can be essential for its function.
The design of REG3α inhibitors often involves detailed studies of the protein's crystal structure to identify key binding pockets and residues that can be exploited. For instance, molecular docking studies are frequently employed to simulate how potential inhibitors interact with REG3α's carbohydrate-binding groove. Chemical scaffolds for these inhibitors might range from small organic molecules that fit into the lectin-binding site to larger compounds that block critical protein-protein interactions or alter REG3α's overall structure. The specificity of these inhibitors is vital, as REG3α shares structural similarities with other members of the Reg family and C-type lectins. This requires careful optimization to avoid off-target interactions with similar proteins. The development of REG3α inhibitors also involves understanding their physicochemical properties, such as solubility, binding affinity, and stability, which are critical for achieving effective inhibition of REG3α activity in various chemical environments.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone may decrease REG3α expression by attenuating the transcriptional activity of pro-inflammatory genes through glucocorticoid receptor-mediated interactions with transcription factors responsible for REG3α synthesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin potentially downregulates REG3α expression by inhibiting the activation of transcription factor AP-1, a known promoter of REG3α in response to inflammatory stimuli within intestinal epithelial cells. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could reduce the synthesis of REG3α by hindering the activation of STAT3, a signaling molecule that, when activated, prompts the expression of REG3α following pro-inflammatory signaling cascades. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin has the potential to decrease REG3α expression by specifically inhibiting mTORC1, a complex that can indirectly enhance REG3α expression by stimulating protein translation and cell proliferation under inflammatory conditions. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may suppress REG3α production by activating the antioxidant response element (ARE) via the KEAP1/Nrf2 pathway, which can lead to the transcriptional repression of certain inflammation-related genes, including REG3α. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate potentially downregulates REG3α by blocking the phosphorylation and subsequent nuclear translocation of NF-κB, which is essential for REG3α gene transcription in response to bacterial pathogen-associated molecular patterns. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin could inhibit the synthesis of REG3α by obstructing the JAK/STAT signaling pathway, which is responsible for the upregulation of REG3α in response to various pro-inflammatory cytokines. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein might decrease REG3α mRNA levels by competitively binding to estrogen receptors, which, when activated, can lead to the upregulation of REG3α in certain types of cells within the gastrointestinal tract. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylic acid could repress REG3α expression by preventing the activation of the COX-2/PGE2 pathway, which is known to mediate inflammation and subsequently promote REG3α expression. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin might reduce REG3α transcription by robustly inhibiting COX enzymes and the subsequent production of prostanoids, which are mediators of inflammation that can stimulate REG3α expression. | ||||||